Study on Mechanism for Preventing Thrombus Formation by Nano-Biological Catheter Pump
Study on Mechanism for Preventing Thrombus Formation by Nano-Biological Catheter Pump
复制标题
纳米生物导管泵预防血栓形成的机制研究
DOI：
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Yonggang Xiong
中科院分区：
文献类型：
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作者：
Wanpeng Tian;Yonggang Xiong
基于Grigioni和Danny Bluestein提出的血栓预测模型，应用计算流体力学（CFD）方法研究了纳米生物导管泵预防血栓形成的机理。血小板的剪切力和暴露时间
计算纳米生物导管泵的运动，分析血小板活化状态（PAS），模拟纳米生物导管泵的血栓形成，预测血栓形成，预防血栓的发生。通过计算分析，
结果表明，当纳米生物导管泵的流量为3.8 L/min，转速为9800 r/min，扬程为14.798 kPa时，该泵可满足左心室泵的要求。Grigioni和Danny Bluestein预测模型的PAS为6.39 × 10-6
和7.68 × 10-4。由于数值较小，血栓几乎从未形成。探讨其防止血栓形成的机理，预测泵的水力性能，可为泵的结构优化提供理论依据。
泵。
Based on prediction model for thrombus proposed by Grigioni and Danny Bluestein, the mechanism for preventing thrombus formation by a Nano-biological catheter pump was studied herein by applying computational fluid dynamics (CFD). The shearing force and exposure time for platelets during
the movement of nano-biologic catheter pump were calculated, and the platelet activation state (PAS) was analyzed, so as to simulate thrombus formation of Nano-biologic catheter pump, predict the thrombus formation and prevent the occurrence of thrombus. Through calculation and analysis, it
was shown that the pump can meet the requirements for left ventricle pump when the flow rate of the Nano-biological catheter pump is 3.8 L/min, the rotation speed is 9800 r/min and the head is 14.798 kPa. PAS in the prediction model by Grigioni and Danny Bluestein were 6.39 × 10–6
and 7.68 × 10–4, respectively. Since the values were small, the thrombus almost never formed. To explore the mechanism for preventing thrombus formation, and prediction of hydraulic performance of the pump can provide theoretical basis for optimizing the structure of
the pump.