Neuroendocrine profiles associated with energy intake, sleep, and stress in the night eating syndrome
Neuroendocrine profiles associated with energy intake, sleep, and stress in the night eating syndrome
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DOI：
10.1210/jc.2005-1018
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发表时间：
2005-11-01
影响因子：
5.8
通讯作者：
Stunkard, AJ
中科院分区：
文献类型：
--
作者：
Allison, KC;Ahima, RS;Stunkard, AJ
背景：夜间进食综合征（内斯）的特征是夜间进食过多和频繁的食物摄入唤醒。它与肥胖和抑郁情绪有关。更好地了解激素对内斯的影响是可取的。目的：我们的目标是评估25小时档案的激素参与能量平衡，睡眠，并强调在内斯。设计：血糖，胰岛素，生长激素释放肽，瘦素，褪黑激素，皮质醇，促甲状腺激素，催乳素血液化验重复采样之间内斯和对照组。食物摄入量和抑郁症状进行了assessed.Setting和Participants：15内斯和14匹配的对照组参与者在一个综合临床研究Center.Main结果Measures：我们评估了内斯和对照组参与者之间的差异在25小时的档案8 hormone.Results：夜间食物摄入量较高的内斯参与者，虽然他们的每日热量摄入量是类似的控制。内斯组的胰岛素（P < 0.001）和葡萄糖（P = 0.07）水平高于对照组，反映了他们夜间摄入量的增加。从0100-0900 h，内斯参与者的Ghrelin水平显著低于对照组（P = 0.003）。血浆皮质醇，褪黑激素，瘦素和催乳素水平没有组间差异，但有一个趋势，促甲状腺激素水平（P = 0.07），在25小时内，内斯。内斯组抑郁症状明显高于对照组（P < 0.001）。内斯组和对照组之间葡萄糖、胰岛素和生长激素释放肽水平的差异与夜间食物摄入密切相关。
Context: Night eating syndrome (NES) is characterized by evening hyperphagia and frequent awakenings with ingestion of food. It is associated with obesity and depressed mood. Greater understanding of hormonal influences on NES is desirable.Objective: Our objective was to evaluate 25-h profiles of hormones involved in energy balance, sleep, and stress in NES.Design: Blood assays for glucose, insulin, ghrelin, leptin, melatonin, cortisol, TSH, and prolactin were sampled repeatedly among NES and control subjects. Food intake and depressive symptoms were assessed.Setting and Participants: Fifteen NES and 14 matched control participants stayed three nights in a General Clinical Research Center.Main Outcome Measures: We assessed differences between NES and control participants in the 25-h profiles of eight hormones.Results: Nocturnal food intake was higher among NES participants, although their daily calorie intake was similar to that of controls. Reflecting their increased nocturnal intake, insulin (P < 0.001) and glucose levels (P = 0.07) among NES participants were higher than those of controls. Ghrelin levels were significantly lower in NES participants than in controls from 0100-0900 h (P = 0.003). Levels of plasma cortisol, melatonin, leptin, and prolactin did not differ between groups, but there was a trend for TSH levels (P = 0.07) to be higher during the 25 h in NES. NES participants had greater depressive symptoms than controls (P < 0.001). The differences in the levels of glucose, insulin, and ghrelin between NES and controls are closely associated with nocturnal food intake.