Studies on drug-induced lipidosis. 3. Lipid composition of the liver and some other tissues in clinical cases of "Niemann-Pick-like syndrome" induced by 4,4'-diethylaminoethoxyhexestrol.
Studies on drug-induced lipidosis. 3. Lipid composition of the liver and some other tissues in clinical cases of "Niemann-Pick-like syndrome" induced by 4,4'-diethylaminoethoxyhexestrol.
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药物引起的脂质沉积症的研究。
DOI：
10.1093/oxfordjournals.jbchem.a129695
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发表时间：
1971
影响因子：
2.7
通讯作者：
T. Kitani
中科院分区：
文献类型：
--
作者：
A. Yamamoto;S. Adachi;K. Ishikawa;T. Yokomura;T. Kitani
本文对7例4，4‘-二乙氨基-乙氧基己酮二盐酸盐所致的“泡沫细胞综合征”患者的肝脏和其他组织的脂质成分进行了测定。肝脏中游离胆固醇和总磷脂含量升高。磷脂分析显示，肝脏中的溶双磷脂酸和磷脂酰肌醇显著增加。在脾、肌肉、淋巴结和尿沉渣中也检测到溶二磷脂酸的增加。但是，这种磷脂在白细胞中并没有增加。4，4‘-二乙氨基乙氧基己酮本身的累积是通过总脂的薄层层析检测到的。对总甾醇的气相色谱分析显示，组织和血清中的桥本甾醇增加。该综合征在某些方面类似于尼曼-皮克病。讨论了特殊的甘油磷脂--溶二磷脂酸的积累机理。
Lipid composition of liver and some other tissues was determined in seven cases of “foam cell syndrome” which was induced by the administration of 4, 4′-diethylamino-ethoxyhexestrol dihydrochloride. Free cholesterol and total phospholipids were increased in the liver. Phospholipid analysis showed marked increases in lysobisphos-phatidic acid and phosphatidylinositol in liver. An increase in lysobisphosphatidic acid was also detected in spleen, muscle, lymph nodes and urinary sediment. However, this phospholipid was not increased in leucocytes.Accumulation of 4, 4′-diethylaminoethoxyhexestrol itself was detected by thin layer chromatography of total lipids. Gas chromatographic analysis of the total sterol showed an increase in desmosterol in tissues and in blood serum.The syndrome resembles Niemann-Pick disease in some respects. Discussion is made on the mechanism of accumulation of the peculiar glycerophospholipid, lysobisphosphatidic acid.