Alterations in single muscle fiber calcium sensitivity with resistance training in older women
Alterations in single muscle fiber calcium sensitivity with resistance training in older women
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DOI：
10.1007/s00424-002-0821-1
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发表时间：
2002-06-01
影响因子：
4.5
通讯作者：
Trappe, SW
中科院分区：
文献类型：
--
作者：
Godard, MP;Gallagher, PM;Trappe, SW
The purpose of this investigation was to determine the effects of a 12-week progressive resistance-training program (PRT) on single muscle fiber calcium sensitivity in six older women (73 +/- 2 years). Muscle biopsy samples of the vastus lateralis were obtained pre- and post-PRT. Chemically skinned single muscle fibers (n=274) were dissected and studied. The experimental sequence for each fiber was the determination of peak maximal isometric tension (P-o) at pCa 4.5 (pCa=-log[Ca2+]), and then subsequent submaximal activations of the fiber at nine Ca2+ concentrations (pCa 6.8 to 4.7). Myosin heavy chain (MHC) I fiber (slow-twitch) diameter increased 16% (P
