Mapping therapeutic response in a patient with malignant glioma.
Mapping therapeutic response in a patient with malignant glioma.
复制标题
绘制恶性神经胶质瘤患者的治疗反应。
DOI：
10.1097/00004728-200107000-00004
复制
发表时间：
2001
影响因子：
1.3
通讯作者：
Toga,AW
中科院分区：
文献类型：
--
作者：
Haney,SM;Thompson,PM;Cloughesy,TF;Alger,JR;Frew,AJ;Torres-Trejo,A;Mazziotta,JC;Toga,AW
患者的短间隔扫描提供了对肿瘤组织自然进展的详细了解，如治疗前通过成像标记物（如对比增强和水肿）所显示的。治疗后，短间隔扫描还可以提供生长率减弱的证据。我们提出了一个纵向成像研究的病人与多形性胶质母细胞瘤（GBM）扫描15次，在104天的3T MR扫描仪。通过两种能够创建肿瘤变化的详细图以及体积分析的自动化算法独立地分析图像。该算法，最近邻为基础的组织分割和表面建模算法，跟踪病人的反应替莫唑胺，显示衰减的增长。需要替代成像终点，其中生长率是一个例子，进行了讨论。此外，这些算法的优势，通过短间隔扫描获得的洞察力，以及需要更好地了解成像标记物也进行了描述。
Short-interval scanning of patients offers a detailed understanding of the natural progression of tumor tissue, as revealed through imaging markers such as contrast enhancement and edema, prior to therapy. Following treatment, short-interval scanning can also provide evidence of attenuation of growth rates. We present a longitudinal imaging study of a patient with glioblastoma multiforme (GBM) scanned 15 times in 104 days on a 3 T MR scanner. Images were analyzed independently by two automated algorithms capable of creating detailed maps of tumor changes as well as volumetric analysis. The algorithms, a nearest-neighbor-based tissue segmentation and a surface-modeling algorithm, tracked the patient's response to temozolomide, showing an attenuation of growth. The need for surrogate imaging end-points, of which growth rates are an example, is discussed. Further, the strengths of these algorithms, the insight gained by short-interval scanning, and the need for a better understanding of imaging markers are also described.