Hepatoprotective effect of vitamin B12 on dimethylnitrosamine-induced liver injury
Hepatoprotective effect of vitamin B12 on dimethylnitrosamine-induced liver injury
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DOI：
10.1248/bpb.31.309
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发表时间：
2008-02-01
影响因子：
2
通讯作者：
Yagi, Kiyohito
中科院分区：
文献类型：
--
作者：
Isoda, Katsuhiro;Kagaya, Noritaka;Yagi, Kiyohito
维生素B-12含有钴复合体，在肝脏中积聚水平较高。观察维生素B-12对二甲基亚硝胺所致小鼠肝损伤的保护作用。维生素B-12能降低血中天冬氨酸氨基转移酶和丙氨酸氨基转移酶的水平，并明显抑制胶原纤维的过度聚集。肝脏逆转录聚合酶链式反应(RT-PCR)分析显示，维生素B-12可抑制肝纤维化标志物α-平滑肌肌动蛋白和热休克蛋白47的基因表达。我们的研究结果表明，维生素B-12可能是一种有效的肝脏保护剂。
Vitamin B-12 contains a cobalt complex and accumulates at high levels in the liver. Vitamin B-12 was examined for its hepatoprotective effect on dimethylnitrosamine-induced liver injury in mice. Vitamin B-12 decreased the blood levels of aspartate aminotransferase and alanine aminotransferase, and clearly inhibited the overaccumulation of collagen fibrils. Reverse transcription-polymerase chain reaction (RT-PCR) analysis of the liver showed that the gene expression of alpha-smooth muscle actin and heat-shock protein 47, which are markers of fibrosis, were suppressed by vitamin B-12 administration. Our findings indicate that vitamin B-12 could be an effective hepatoprotective agent.