ASSOCIATION OF CROSSOVER POINTS WITH TOPOISOMERASE-I CLEAVAGE SITES - A MODEL FOR NONHOMOLOGOUS RECOMBINATION
ASSOCIATION OF CROSSOVER POINTS WITH TOPOISOMERASE-I CLEAVAGE SITES - A MODEL FOR NONHOMOLOGOUS RECOMBINATION
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DOI：
10.1126/science.2997924
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
BOTCHAN, M
中科院分区：
文献类型：
--
作者：
BULLOCK, P;CHAMPOUX, JJ;BOTCHAN, M
Nonhomologous DNA recombination is frequently observed in somatic cells upon the introduction of DNA into cells or in chromosomal events involving sequences already stably carried by the genome. In this report, the DNA sequences at the crossover points for excision of SV40 from chromosomes were shown to be associated with eukaryotic topoisomerase I cleavage sites in vitro. The precise location of the cleavage sites relative to the crossover points has suggested a general model for nonhomologous recombination mediated by topoisomerase I.
