Gating of sensory information differs in patients with interstitial cystitis/painful bladder syndrome.
Gating of sensory information differs in patients with interstitial cystitis/painful bladder syndrome.
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DOI：
10.1016/j.juro.2010.04.083
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发表时间：
2010-09
期刊：
影响因子：
--
通讯作者：
Naliboff BD
中科院分区：
文献类型：
--
作者：
Kilpatrick LA;Ornitz E;Ibrahimovic H;Hubbard CS;Rodríguez LV;Mayer EA;Naliboff BD
Altered sensory processing in interstitial cystitis/painful bladder syndrome (IC/PBS) may result from a deficiency of the central nervous system to adequately filter incoming visceral afferent information. The current study used prepulse inhibition (PPI) as an operational measure of sensorimotor gating to examine early pre-attentive stages of information processing in female IC/PBS and healthy controls (HCs). PPI was assessed in female IC/PBS patients (n=14) and HCs (n=17) with 60 ms and 120 ms prepulse-to-startle stimulus intervals. Group differences in PPI and relationships between PPI, neuroticism, and acute stress ratings were evaluated. Patients showed significantly reduced PPI at both 60 ms and 120 ms prepulse intervals. The PPI deficit was related to acute stress ratings in the IC/PBS patients. However, increased neuroticism appeared to mitigate the PPI deficit in IC/PBS, possibly reflecting greater vigilance. Compared to HCs, female IC/PBS patients demonstrated a decreased ability to adequately filter incoming information and perform appropriate sensorimotor gating. These results suggest that a possible mechanism for altered interoceptive information processing in IC/PBS may be the presence of a general deficit in filtering mechanisms due to altered pre-attentive processing.
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影响因子：
2
作者：
FitzGerald, MP;Koch, D;Senka, J
通讯作者：
Senka, J
影响因子：
10.6
作者：
Hazlett, EA;Buchsbaum, MS;Haznedar, MM
通讯作者：
Haznedar, MM
影响因子：
10.6
作者：
Ornitz, EM;Russell, AT;Guthrie, D
通讯作者：
Guthrie, D
影响因子：
6.6
作者：
Twiss, Christian;Kilpatrick, Lisa;Naliboff, Bruce D.
通讯作者：
Naliboff, Bruce D.
DOI：
10.1073/pnas.0800969105
发表时间：
2008-07-29
影响因子：
11.1
作者：
Rickenbacher, Elizabeth;Baez, Madelyn A.;Valentino, Rita J.
通讯作者：
Valentino, Rita J.