Green synthesis of chitosan-based nanofibers and their applications
Green synthesis of chitosan-based nanofibers and their applications
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DOI：
10.1039/b927125b
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发表时间：
2010-07
期刊：
影响因子：
9.8
通讯作者：
L. Qian;Haifei Zhang
中科院分区：
文献类型：
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作者：
L. Qian;Haifei Zhang
本文报道了一种简单、绿色的制备壳聚糖和壳聚糖基纳米纤维的方法，即通过冷冻干燥稀水溶液，不使用有机溶剂、高浓度酸溶液，也不需要对壳聚糖进行预处理。从浓度等于或低于0.1wt%的壳聚糖水溶液中获得直径范围为100至700 nm的壳聚糖纳米纤维。将壳聚糖/聚乙烯醇共混物溶液冷冻干燥，制备了不同质量比的壳聚糖/聚乙烯醇共混纳米纤维。研究了溶液浓度、壳聚糖分子量和冷冻温度对壳聚糖冷冻效果的影响。分析了纳米纤维的形貌和热稳定性。测量散装纤维材料的孔径和孔体积。在5倍浓度的模拟体液中，磷酸钙在壳聚糖纳米纤维上形成了均匀的涂层。研究了壳聚糖纳米纤维对水溶液中铜离子的吸附性能。结果发现，对于浓度为1000 ppm的CuSO 4水溶液，壳聚糖纳米纤维在2.57 mmol g−1时表现出对Cu 2+的高吸附容量。研究了壳聚糖纳米纤维作为支架对小分子（罗丹明B）和蛋白质分子（牛血清白蛋白）的负载和释放。
We report here a simple and green method for the preparation of chitosan and chitosan-based nanofibers by freeze-drying dilute aqueous solutions, without the use of organic solvent, high concentration of acid solutions, or the need to pre-treat chitosan. Chitosan nanofibers with diameters ranging from 100 to 700 nm were obtained from aqueous chitosan solutions with the concentrations equal to or below 0.1 wt %. Chitosan/poly(vinyl alcohol) blend nanofibers with different mass ratios were produced by freeze-drying the mixture solutions. The effects of solution concentration, chitosan molecular weight, and freezing temperature were examined. The morphology and thermal stability of the nanofibers were analyzed. Pore size and pore volume of the bulk fibrous materials were measured. A uniform coating of calcium phosphate was formed on the chitosan nanofibers in a 5 times concentrated simulated body fluid. The adsorption of copper ions by chitosan nanofibers from aqueous solutions was investigated. It was found that chitosan nanofibers exhibited a high adsorption capacity of Cu2+ at 2.57 mmol g−1 of chitosan for aqueous CuSO4 solution at a concentration of 1000 ppm. Loading and release of small molecules (Rhodamine B) and protein molecules (bovine serum albumin) with chitosan nanofibers as scaffolds were also investigated.