Orexin Directly Enhances the Excitability of Globus Pallidus Internus Neurons in Rat by Co-activating OX1 and OX2 Receptors
Orexin Directly Enhances the Excitability of Globus Pallidus Internus Neurons in Rat by Co-activating OX1 and OX2 Receptors
复制标题
Orexin 通过共激活 OX1 和 OX2 受体直接增强大鼠苍白球内部神经元的兴奋性
DOI：
10.1007/s12264-017-0127-0
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发表时间：
2017-08-01
影响因子：
5.6
通讯作者：
Zhu, Jing-Ning
中科院分区：
文献类型：
--
作者：
Gao, He-Ren;Zhuang, Qian-Xing;Zhu, Jing-Ning
Orexin, released from the hypothalamus, has been implicated in various basic non-somatic functions including feeding, the sleep-wakefulness cycle, emotion, and cognition. However, the role of orexin in somatic motor control is still little known. Here, using whole-cell patch clamp recording and immunostaining, we investigated the effect and the underlying receptor mechanism of orexin-A on neurons in the globus pallidus internus (GPi), a critical structure in the basal ganglia and an effective target for deep brain stimulation therapy. Our results showed that orexin-A induced direct postsynaptic excitation of GPi neurons in a concentration-dependent manner. The orexin-A-induced excitation was mediatedviaco-activation of both OX1 and OX2 receptors. Furthermore, the immunostaining results showed that OX1 and OX2 receptors were co-localized in the same GPi neurons. These results suggest that the central orexinergic system actively modulates the motor functions of the basal gangliaviadirect innervation on GPi neurons and presumably participates in somatic-non-somatic integration.
