Cancer risk in DES daughters
Cancer risk in DES daughters
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DOI：
10.1007/s10552-010-9526-5
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发表时间：
2010-07-01
影响因子：
2.3
通讯作者：
Rookus, Matti A.
中科院分区：
文献类型：
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作者：
Verloop, Janneke;van Leeuwen, Flora E.;Rookus, Matti A.
我们调查了子宫内接触己烯雌酚(DES)的妇女患癌症的长期风险。从1992年12月到2008年6月，我们对荷兰总共12,091名暴露于DES的妇女进行了前瞻性跟踪调查。通过与荷兰病理学数据库(PALGA)和荷兰癌症登记处的链接来评估癌症发病率，并与荷兰女性人口进行比较。总共发生了348例经医学验证的癌症；随访结束时的中位年龄为44.0岁。未发现总体癌症风险增加(标准化发病率比[SIR]=1.01；95%可信区间[CI]=0.91，1.13)。阴道和宫颈透明细胞腺癌(CCA)的风险显著增加(SIR=24.23；95%CI=8.89，52.74)，风险持续在40岁以上。40岁以前确诊为黑色素瘤的危险性增加(SIR=1.59；95%CI=1.08、2.26)。没有发现包括乳腺癌在内的其他部位的额外风险。除了CCA的风险增加，在老年持续存在，以及在年轻时黑色素瘤的风险增加外，我们没有发现癌症风险增加。有必要进行更长时间的随访，以检查癌症发生频率较高的年龄段的癌症风险。
We examined long-term risk of cancer in women exposed to diethylstilbestrol (DES) in utero.A total of 12,091 DES-exposed women in the Netherlands were followed prospectively from December 1992 till June 2008. Cancer incidence was assessed through linkage with the Dutch pathology database (PALGA) and the Netherlands Cancer Registry and compared with the Dutch female population.A total of 348 medically verified cancers occurred; median age at end of follow-up was 44.0 years. No overall increased risk of cancer was found (standardized incidence ratio [SIR] = 1.01; 95% confidence interval [CI] = 0.91, 1.13). The risk of clear cell adenocarcinoma of the vagina and cervix (CCA) was statistically significantly increased (SIR = 24.23; 95% CI = 8.89, 52.74); the elevated risk persisted above 40 years of age. The risk of melanoma diagnosed before age 40 was increased (SIR = 1.59; 95% CI = 1.08, 2.26). No excess risks were found for other sites, including breast cancer.Except for an elevated risk of CCA, persisting at older ages, and an increased risk of melanoma at young ages, we found no increased risk of cancer. Longer follow-up is warranted to examine cancer risk at ages when cancer occurs more frequently.