Extracellular and intracellular factors regulating the migration direction of a chemotactic cell in traveling-wave chemotaxis
Extracellular and intracellular factors regulating the migration direction of a chemotactic cell in traveling-wave chemotaxis
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DOI：
10.1088/1478-3975/12/2/026004
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发表时间：
2015-04-01
期刊：
影响因子：
2
通讯作者：
Iwasa, M.
中科院分区：
文献类型：
--
作者：
Ishiwata, R.;Iwasa, M.
这份报告提出了一个简单的模型，描述了一个单一的盘基网柄菌细胞在环磷酸腺苷(CAMP)的行波中的运动。该模型结合了对cAMP刺激的两种类型的反应：细胞的极性和运动性的变化。在前人实验研究的基础上，假设运动的周期性变化是由周期性的cAMP刺激引起的。因此，细胞的净迁移发生在相对于波传播的特定方向上，这解释了盘状芽孢杆菌细胞聚集的迁移。波周期和两次响应时间之差是决定偏移方向的重要参数。理论预测与另一项研究中的实验进行了比较。从盘藻细胞群体的单细胞状态到聚集状态的转变被理解为生物学中对称性自发破坏的一个具体例子。
This report presents a simple model that describes the motion of a single Dictyostelium discoideum cell exposed to a traveling wave of cyclic adenosine monophosphate (cAMP). The model incorporates two types of responses to stimulation by cAMP: the changes in the polarity and motility of the cell. The periodic change in motility is assumed to be induced by periodic cAMP stimulation on the basis of previous experimental studies. Consequently, the net migration of the cell occurs in a particular direction with respect to wave propagation, which explains the migration of D. discoideum cells in aggregation. The wave period and the difference between the two response times are important parameters that determine the direction of migration. The theoretical prediction compared with experiments presented in another study. The transition from the single-cell state of the population of D. discoideum cells to the aggregation state is understood to be a specific example of spontaneous breakage of symmetry in biology.