Reflectance pulse oximetry measurements from the retinal fundus
Reflectance pulse oximetry measurements from the retinal fundus
复制标题
视网膜眼底反射脉搏血氧饱和度测量
DOI：
--
复制
发表时间：
1993
影响因子：
4.6
通讯作者：
Adrian Robert
中科院分区：
文献类型：
--
作者：
de Kock;Lionel Tamssenko;Christopher James Glynn;Adrian Robert
传统的传输脉搏血氧仪是一种无创技术，用于从周围血管床（如指尖或耳垂）连续监测动脉氧饱和度（SaO/sub 2/）。提出利用眼介质独特的透明性对视网膜眼底进行反射性脉搏血氧测量。与传统的脉搏血氧仪相比，这项技术具有潜在的显著优势，主要在于能够监测大脑的氧饱和度，而不是外周的氧饱和度。建立了模拟视网膜循环和眼光学的体外系统。该系统由位于模型眼内的柔性试管和模拟动脉血流的体外血液回路组成。利用该系统研究了反射式脉搏血氧测定中SaO/sub 2/与R/IR比值的关系。为了能够在体内进行测量，对标准触觉隐形眼镜进行了修改，使脉搏血氧计探头位于瞳孔前方。在初步研究中，将该透镜安装在清醒的志愿者身上，并通过视网膜脉搏血氧仪检测心脏同步信号
Conventional transmission pulse oximetry is a noninvasive technique for the continuous monitoring of arterial oxygen saturation (SaO/sub 2/) from peripheral vascular beds such as the finger tip or earlobe. It is proposed to exploit the unique transparency of the ocular media to make reflectance pulse oximetry measurements on the retinal fundus. This technique potentially offers significant advantages over conventional pulse oximetry, primarily in the ability to monitor cerebral, as opposed to peripheral, oxygen saturation. An in vitro system has been developed to simulate the retinal circulation and ocular optics. This system consists of a flexible cuvette located in a model eye and an extracorporeal blood circuit to simulate arterial blood flow. The system was used to investigate the relationship between SaO/sub 2/ and the R/IR ratio in reflectance pulse oximetry. To enable in vivo measurements to be made, a standard haptic contact lens was modified to hold the pulse oximeter probe in front of the pupil. In a preliminary study, the lens was fitted to an awake volunteer and cardiac-synchronous signals were detected by the retinal pulse oximeter.<<ETX>>