Is nicotine important in tobacco smoking?
Is nicotine important in tobacco smoking?
复制标题
尼古丁对吸烟重要吗？
DOI：
10.1002/cpt1977215520
复制
发表时间：
1977
影响因子：
6.7
通讯作者：
M. Russell
中科院分区：
文献类型：
--
作者：
R. Kumar;E. Cooke;M. Lader;M. Russell
吸烟通常被认为是尼古丁依赖的一种形式，但这方面的证据很少。这里描述了两个实验，它们检验了一个假设，即习惯性吸烟者需要尼古丁，并且他们调节这种药物的摄入量。设计了一个吸烟的实验室测试，允许连续监测吸烟以及选定的生理变量；该程序还旨在减少吸烟习惯和仪式的影响。在第一个实验中，吸入的烟草烟雾量以剂量相关的方式减少了随后的随意吸烟。在第二个实验中，同样的受试者静脉注射了相同剂量的尼古丁，但对持续吸烟没有影响。然而，吸入和静脉注射剂量的药物产生了非常相似的生理效应。因此，这些实验并不支持尼古丁依赖假说；因此，这种药物维持吸烟习惯的方式，如果有的话，值得进一步研究。
Tobacco smoking is generally regarded as a form of nicotine dependence, but the evidence for this is slender. Two experiments are described here which examine the hypothesis that habitual smokers need nicotine and that they regulate their intakes of this drug. A laboratory test for smoking was devised which permitted the continuous monitoring of puffing as well as of selected physiologic variables; the procedure was also designed to reduce the influence of smoking habits and rituals. In the first experiment, inhaled amounts of tobacco smoke reduced subsequent ad libitum smoking in a dose‐related way. In the second experiment comparable doses of nicotine were given intravenously to the same subjects, but they failed to affect ongoing smoking. However, both the inhaled and intravenous doses of the drug produced very similar physiologic effects. These experiments do not, therefore, support the nicotine‐dependence hypothesis; thus the ways, if any, in which this drug sustains the tobacco‐smoking habit merit further examination.