Distribution of lipoproteins by age and gender in adolescents
Distribution of lipoproteins by age and gender in adolescents
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DOI：
10.1161/circulationaha.106.620864
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发表时间：
2006-09-05
期刊：
影响因子：
37.8
通讯作者：
Janssen, Ian
中科院分区：
文献类型：
--
作者：
Jolliffe, Courtney J.;Janssen, Ian
背景-目前的国家胆固醇教育计划脂蛋白分类系统的儿童和青少年推荐使用2至19岁的青少年。这种分类系统不考虑性别差异或脂蛋白浓度的自然波动，发生与growth and maturation.Methods和结果-数据从国家健康和营养检查调查被用来开发年龄和性别特异性阈值，可用于表示异常水平的总胆固醇，低密度脂蛋白胆固醇，高密度脂蛋白胆固醇和甘油三酯。使用LMS（Lambda-Mu-Sigma）生长曲线回归方法将每条曲线与成人国家胆固醇教育计划成人治疗组III脂蛋白阈值相关联。一系列的增长曲线和表格，可用于诊断高风险脂蛋白水平的临床和研究设置。例如，男性从12岁开始到19岁，以1年为增量，总胆固醇的高风险阈值分别为6.03、5.83、5.70、5.70、5.77、5.88、6.02和6.16 mmol/L。成人（>= 20岁）相应的高风险阈值为6.22 mmol/L。结论-本研究是首次尝试开发青少年的年龄和性别特异性脂蛋白阈值浓度。这一新的分类系统应能更准确地诊断青少年的高危脂蛋白水平和相关的心血管风险。
Background - The current National Cholesterol Education Program lipoprotein classification system for children and adolescents is recommended for use among 2- to 19-year-olds. This classification system does not take into account gender differences or the natural fluctuations in lipoprotein concentrations that occur with growth and maturation.Methods and Results - Data from the National Health and Nutrition Examination Surveys were used to develop age- and gender-specific thresholds that can be used to denote abnormal levels of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides. Each curve was linked to the adult National Cholesterol Education Program Adult Treatment Panel III lipoprotein thresholds using LMS (Lambda-Mu-Sigma) growth curve regression methods. A series of growth curves and tables are presented that can be used to diagnose high-risk lipoprotein levels in the clinical and research settings. For example, in 1-year increments for males starting at age 12 and extending to age 19 years, the high-risk thresholds for total cholesterol were 6.03, 5.83, 5.70, 5.70, 5.77, 5.88, 6.02, and 6.16 mmol/L. The corresponding high-risk threshold for adults (>= 20 years) is 6.22 mmol/L.Conclusions - The present study is the first attempt at developing age- and gender-specific lipoprotein threshold concentrations for adolescents. This new classification system should provide a more accurate diagnosis of high-risk lipoprotein levels and associated cardiovascular risks in adolescents.