The clinical features of intractable allergic rhinitis based on a questionnaire administered to clinicians.
The clinical features of intractable allergic rhinitis based on a questionnaire administered to clinicians.
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基于对临床医生进行的问卷调查的顽固性过敏性鼻炎的临床特征。
DOI：
10.1016/j.alit.2020.12.003
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Fujieda S.
中科院分区：
文献类型：
--
作者：
2.Imoto Y;Sakashita M;Hayama M;Nakamaru Y;Suzuki M;Miyabe Y;Yamada T;Saito H;Yonekura S;Kondo K;Higaki T;Kawashima K;Urashima M;Fujieda S.
变应性鼻炎(AR)可能看起来不是一种严重的疾病，因为它与严重的发病率和死亡率无关，但这些症状会显著影响患者的生活质量(QOL)。在日本，日本雪松花粉(JCP)和屋尘螨是常见的过敏原，1而且AR患者的数量一直在增加。2 AR指南提供了根据过敏症状的严重程度制定治疗计划的算法。1治疗的目的是减轻症状，提高患者的生活质量。尽管指导药物治疗，10%-20%的严重AR患者仍然受到他们的症状的困扰。3这类病例是否代表了一种“难治”的AR？目前，还没有确定顽固性AR的标准。在本研究中，我们试图确定顽固性常年性AR(PAR)或季节性AR(SAR)患者的特征。我们向临床医生发放了问卷，这些项目被认为是由尘螨或JCP引起的SAR(SAR-JCP)引起的顽固性PAR的潜在临床特征。问卷共有10个项目：每个项目都经过所有作者的仔细讨论和选择(表1，2)。临床医生被要求选出三项他们认为最重要的临床特征，并根据重要性对这三项进行排序。我们将最重要的项目作为顽固性AR的临床特征，评分如下：最重要的项目(第1名)得3分，第二重要的项目(第2名)得2分，第3重要的项目(第3名)得1分。将每个项目的得分相加(显示为总分)，并计算临床医生的平均得分，以确定每个项目的排名。调查在2018年6月至8月期间进行，共向5800名临床医生发放了问卷；其中包括日本鼻科学会的1846名耳鼻喉科医生和日本过敏学会的3954名过敏专家，其中包括拥有行医执照的内科医生、眼科医生、皮肤科医生、儿科医生和基础科学家。共有2787名临床医生(48.1%)回答了问卷(补充表1)。在由粉尘引起的顽固性PAR中，平均得分最高的是口试要求
Allergic rhinitis (AR) might not appear to be a serious disease since it is not associated with severe morbidity and mortality, but, the symptoms can significantly impair the quality of life (QOL) of the patients. In Japan, Japanese cedar pollen (JCP) and house dust mites are common allergens, 1 and the number of AR patients has been increasing. 2 The guidelines for AR provide algorithms for developing treatment plans that depend on the severity of the allergic symptoms. 1 The goals of treatment are to reduce symptoms and to improve the QOL of the patients. Despite guideline-directed pharmacotherapy, 10% e20% of severe AR patients remain bothered by their symptoms. 3 Do such cases represent an “intractable” form of AR? Currently, there are no criteria for the determination of intractable AR. In the present study, we attempted to determine the characteristics of patients with intractable perennial AR (PAR) or seasonal AR (SAR). We administered questionnaires to clinicians with items considered to be potential clinical features of intractable PAR caused by mites or SAR due to JCP (SAR-JCP). There were ten items on the questionnaire: each item was carefully discussed and chosen by all of the authors (Table 1, 2). The clinicians were asked to choose three items that they considered to be the most important clinical features of intractable PAR caused by mites or SAR-JCP with unsatisfactory nasal symptoms despite guideline-directed pharmacotherapy, and to rank the three items according to importance. We assigned scores as follows to identify the items with the most importance as clinical features of intractable AR: the most important item (1st place) was assigned 3 points; the second most important item (2nd place) was assigned 2 points; and the third most important item (3rd place) was assigned 1 point. The scores for each item were summed (shown as the total score), and the average score among the clinicians was calculated to identify the rank of each item. The survey was conducted between June and August 2018.The questionnaire was distributed to a total of 5800 clinicians; these included 1846 otorhinolaryngologists belonging to the Japanese Rhinologic Society and 3954 allergy specialists belonging to the Japanese Society of Allergology, including physicians, ophthalmologists, dermatologists, pediatricians, and basic scientists who have a medical license. A total of 2787 clinicians (48.1%) responded to the questionnaire (Supplementary Table 1). Concerning intractable PAR caused by mites, the most important item that showed the highest average score was the requirement of oral
影响因子：
14.2
作者：
Brozek, Jan L.;Bousquet, Jean;Schunemann, Holger J.
通讯作者：
Schunemann, Holger J.
影响因子：
10.3
作者：
Proudfoot, L. E.;Powell, A. M.;Flohr, C.
通讯作者：
Flohr, C.