Determining the Differential Effects of Stretch and Growth in Tissue-Expanded Skin: Combining Isogeometric Analysis and Continuum Mechanics in a Porcine Model.
Determining the Differential Effects of Stretch and Growth in Tissue-Expanded Skin: Combining Isogeometric Analysis and Continuum Mechanics in a Porcine Model.
复制标题
DOI：
10.1097/dss.0000000000001228
复制
发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Gosain AK
中科院分区：
文献类型：
--
作者：
Purnell CA;Gart MS;Buganza-Tepole A;Tomaszewski JP;Topczewska JM;Kuhl E;Gosain AK
组织扩张过程中皮肤生长和拉伸的相对影响尚未研究。作者使用了新颖的分析技术，可以在皮肤贴片的任何点计算这些因素。作者试图确定拉伸和生长如何随着不同的扩张率而变化，并将这些值与皮肤的组织学和细胞变化相关联。两只小型猪在纹身皮肤网格下植入了总共 5 个组织扩张器。一只猪的繁殖时间超过 35 天，第二只猪的繁殖时间超过 15 天。等几何分析允许计算生长和拉伸。对协议之间具有相似总变形的扩展器进行了比较。回归分析确定了拉伸和生长对第二只动物的组织学数据的预测效果。与慢速扩张相比，变形更多地归因于快速扩张（1.40 vs1.12，p < .001）。缓慢扩张时的增长率高于快速扩张时的增长率（1.52 vs 1.07，p < .001）。生长和拉伸都预测表皮厚度、真皮变薄和角质形成细胞增殖。生长预示着血管分布。等几何分析可以确定精确的表面积变化，以便与微观数据相关。使用该模型，作者发现快速扩张时的皮肤变形更多地归因于拉伸。
The relative effects of skin growth and stretch during tissue expansion have not been studied. The authors use novel analytic techniques that allow calculation of these factors at any point of a skin patch. The authors sought to determine how stretch and growth change with different expansion rates and to correlate these values with histologic and cellular changes in skin. Two minipigs were implanted with a total of 5 tissue expanders under tattooed skin grids. One pig was expanded over 35 days and the second over 15 days. Isogeometric analysis allowed calculation of growth and stretch. Expanders with similar total deformation were compared between protocols. Regression analysis determined predictive effects of stretch and growth on histologic data from the second animal. Deformation was more attributable to stretch in rapid than in slow expansion (1.40 vs1.12, p < .001). Growth was higher in slow expansion than in rapid (1.52 vs 1.07, p < .001). Both growth and stretch predicted epidermal thickness, dermal thinning, and keratinocyte proliferation. Growth predicted vascularity. Isogeometric analysis allows determination of precise surface area changes for correlation to microscopic-level data. Using the model, the authors identified that skin deformation in rapid expansion is more attributable to stretch.