Myoglobin-like aerotaxis transducers in Archaea and Bacteria
Myoglobin-like aerotaxis transducers in Archaea and Bacteria
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DOI：
10.1038/35000570
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发表时间：
2000-02-03
期刊：
影响因子：
64.8
通讯作者：
Alam, M
中科院分区：
文献类型：
--
作者：
Hou, SB;Larsen, RW;Alam, M
含血蛋白，如血红蛋白和肌红蛋白，在氧气运输和储存中起着至关重要的作用。细菌和真核生物的珠蛋白氨基酸序列的比较表明，它们有一个早期的共同祖先，尽管这些蛋白质在这两个王国中具有不同的功能（1-6）。到目前为止，在第三个领域古细菌中还没有发现珠蛋白家族的成员。最近对细菌和真核生物信号的研究揭示了一类新的含血蛋白，它们可以作为传感器(7)。到目前为止，还没有在古细菌中发现基于血液的传感器。在这里，我们报道了古细菌中第一个肌红蛋白样的含血蛋白，以及细菌中第一个基于血的空气定向传感器（在古细菌盐盐细菌中称为HemAT-Hs，在枯草芽孢杆菌中称为HemAT-Bs）。这些蛋白质表现出与肌红蛋白相似的光谱特性，并引发气动反应。
Haem-containing proteins such as haemoglobin and myoglobin play an essential role in oxygen transport and storage. Comparison of the amino-acid sequences of globins from Bacteria and Eukarya suggests that they share an early common ancestor, even though the proteins perform different functions in these two kingdoms(1-6). Until now, no members of the globin family have been found in the third kingdom, Archaea. Recent studies of biological signalling in the Bacteria and Eukarya have revealed a new class of haem-containing proteins that serve as sensors(7). Until now, no haem-based sensor has been described in the Archaea. Here we report the first myoglobin-like, haem-containing protein in the Archaea, and the first haem-based aerotactic transducer in the Bacteria (termed HemAT-Hs for the archaeon Halobacterium salinarum, and HemAT-Bs for Bacillus subtilis). These proteins exhibit spectral properties similar to those of myoglobin and trigger aerotactic responses.