METABOLIC EFFECTS OF METFORMIN IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS
METABOLIC EFFECTS OF METFORMIN IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS
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DOI：
10.1056/nejm199508313330903
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发表时间：
1995-08-31
影响因子：
158.5
通讯作者：
GERICH, JE
中科院分区：
文献类型：
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作者：
STUMVOLL, M;NURJHAN, N;GERICH, JE
背景。二甲双胍用于治疗非胰岛素依赖型糖尿病（NIDDM）已有30多年的历史，但其代谢作用和作用机制尚不清楚。在10例患有NIDDM的肥胖患者中，我们使用同位素稀释、间接量热法、生物阻抗和组织平衡技术的组合来评估二甲双胍对全身乳酸、葡萄糖和游离脂肪酸转化、乳酸氧化和乳酸转化为葡萄糖的影响；骨骼肌葡萄糖和乳酸代谢；身体成分;治疗前后四个月的能量消耗二甲双胍治疗使平均（+/-SD）糖化血红蛋白值从13.2+/- 2.2%降至10.5+/- 1.6% (P
Background. The metabolic effects and mechanism of action of metformin are still poorly understood, despite the fact that it has been used to treat patients with non-insulin-dependent diabetes mellitus (NIDDM) for more than 30 years.Methods. In 10 obese patients with NIDDM, we used a combination of isotope dilution, indirect calorimetry, bioimpedance, and tissue-balance techniques to assess the effects of metformin on systemic lactate, glucose, and free-fatty-acid turnover, lactate oxidation and the conversion of lactate to glucose; skeletal-muscle glucose and lactate metabolism; body composition; and energy expenditure before and after four months of treatment.Results. Metformin treatment decreased the mean (+/-SD) glycosylated hemoglobin value from 13.2+/-2.2 percent to 10.5+/-1.6 percent (P