PHOTODYNAMIC THERAPY IN THE TREATMENT OF PANCREATIC-CARCINOMA - DIHEMATOPORPHYRIN ETHER UPTAKE AND PHOTOBLEACHING KINETICS
PHOTODYNAMIC THERAPY IN THE TREATMENT OF PANCREATIC-CARCINOMA - DIHEMATOPORPHYRIN ETHER UPTAKE AND PHOTOBLEACHING KINETICS
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DOI：
10.1111/j.1751-1097.1987.tb04859.x
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发表时间：
1987-11-01
影响因子：
3.3
通讯作者：
WIEMAN, TJ
中科院分区：
文献类型：
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作者：
MANG, TS;WIEMAN, TJ
二血卟啉醚（DHE）摄取和荧光动力学的结果表明，在40 mg kg-1的注射剂量下，胰腺中的浓度为约40-60 μ g DHE g-1组织。以前，这种浓度主要是在网状内皮系统器官中发现的。研究了两种胰腺内癌模型，一种是腺泡起源的（大鼠），一种是导管起源的（仓鼠）。当进行荧光测量和化学提取程序时，两者均显示与正常胰腺相比相等或更高浓度的DHE。光动力疗法（PDT）治疗正常胰腺和胰腺肿瘤产生了不典型的结果。当DHE存在的正常胰腺暴露于来自染料激光器（75 mW cm-2，30 min）的630 nm光时，不发生通过荧光衰减可测量的正常光漂白。然而，胰腺肿瘤以相对正常的荧光衰减模式响应，伴随着老化和可测量的DHE浓度的损失。
Results of dihematoporphryin ether (DHE) uptake and fluorescence kinetics show that the concentration in the pancreas is on the order of 40-60 .mu.g DHE g-1 of tissue at an injected dose of 40 mg kg-1. Previously concentrations on this order have primarily when found in organs of the reticuloendothelial system. Two intra-pancreatic carcinoma models, one of acinar origin (rat) and one of ductal origin (hamster), were studied. Both showed equal or higher concentrations of DHE as compared with normal pancreas when fluorescence measurements and chemical extraction procedures were performed. Photodynamic therapy (PDT) treatment of the normal pancreas and pancreatic tumors yielded atypical results. When the normal pancreas with DHE present is exposed to 630-nm light from a dye laser (75 mW cm-2, 30 min), the normal photobleaching measurable by fluorescence decay does not occur. Yet the pancreatic tumor responds with a relatively normal fluorescence decay pattern, with hemorrhaging and a resultant loss of measurable DHE concentration.