Clonal evolution of acute myeloid leukemia highlighted by latest genome sequencing studies.
Clonal evolution of acute myeloid leukemia highlighted by latest genome sequencing studies.
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最新的基因组测序研究强调了急性髓系白血病的克隆进化
DOI：
10.18632/oncotarget.10850
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发表时间：
2016-09-06
期刊：
影响因子：
--
通讯作者：
Li Z
中科院分区：
文献类型：
--
作者：
Zhang X;Lv D;Zhang Y;Liu Q;Li Z
一个起始细胞可能需要几十年的时间才能变成一个完全转移的肿瘤。DNA突变是在这个过程中积累起来的，包括学术上出现的背景突变，以及选择性地发生在少数癌症基因中的驱动突变，这些突变赋予细胞比其邻居更大的生长优势。一个肿瘤细胞的克隆可能被另一个获得新的突变并生长得更有攻击性的克隆所取代。多年来，肿瘤的进化模式一直是用传统的方法来研究的，这些方法主要是研究一个或几个基因。最新的深度测序技术通过破译肿瘤中几乎所有的基因组畸变，使肿瘤进化的全局视图成为可能。肿瘤克隆和每个克隆在肿瘤进化过程中的命运可以借助变异等位基因频率的概念来描述。在这里，我们总结了急性髓性白血病癌症进化进展的新见解。
Decades of years might be required for an initiated cell to become a fully-pledged, metastasized tumor. DNA mutations are accumulated during this process including background mutations that emerge scholastically, as well as driver mutations that selectively occur in a handful of cancer genes and confer the cell a growth advantage over its neighbors. A clone of tumor cells could be superseded by another clone that acquires new mutations and grows more aggressively. Tumor evolutional patterns have been studied for years using conventional approaches that focus on the investigation of a single or a couple of genes. Latest deep sequencing technology enables a global view of tumor evolution by deciphering almost all genome aberrations in a tumor. Tumor clones and the fate of each clone during tumor evolution can be depicted with the help of the concept of variant allele frequency. Here, we summarize the new insights of cancer evolutional progression in acute myeloid leukemia.