Evolutionary processes among sylvatic dengue type 2 viruses
Evolutionary processes among sylvatic dengue type 2 viruses
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DOI：
10.1128/jvi.02776-06
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发表时间：
2007-09-01
影响因子：
5.4
通讯作者：
Weaver, Scott C.
中科院分区：
文献类型：
--
作者：
Vasilakis, Nikos;Holmes, Edward C.;Weaver, Scott C.
在东南亚和西非，森林登革热病毒(Dew)在非人灵长类动物和树栖伊蚊之间以地方性循环传播。虽然以前的分析揭示了地方性(人类)露水的进化过程，但对病毒在病程循环中的进化知之甚少。通过对33年来采集的14个登革2型病毒完整编码区的分析，我们发现，地方性和地方性露水的进化变化速度和自然选择模式都是相似的，尽管后者在NS4B蛋白基因上具有独特的高频率的正选择。我们的发现支持最近的一次跨物种传播事件，并表明未来DENV可能会从森林循环中重新出现。
Sylvatic dengue viruses (DEW) are transmitted in an enzootic cycle between nonhuman primates and arboreal Aedes mosquitoes in Southeast Asia and West Africa. Although previous analyses have revealed the evolutionary processes among endemic (human) DEW, little is known about viral evolution in the sylvatic cycle. Through an analysis of 14 complete coding regions of sylvatic Dengue type 2 virus sampled over a 33-year period, we show that both the rate of evolutionary change and the pattern of natural selection are similar among endemic and sylvatic DEW, although the latter have a uniquely high frequency of positive selection in the NS4B protein gene. Our findings support a recent cross-species transmission event and suggest the possibility of future DENV reemergence from the sylvatic cycle.