High glomerular filtration rate is associated with arterial stiffness in Chinese population
High glomerular filtration rate is associated with arterial stiffness in Chinese population
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中国人群的高肾小球滤过率与动脉僵硬度相关
DOI：
10.1097/hjh.0000000000001158
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发表时间：
2017-02-01
影响因子：
4.9
通讯作者：
Lu, Jieli
中科院分区：
文献类型：
--
作者：
Lin, Lin;Peng, Kui;Lu, Jieli
目的：肾小球滤过率（GFR）降低被怀疑是动脉硬化的危险因素。高 GFR 是否是动脉硬化和心血管疾病的危险因素仍不确定。我们的目的是评估中国成年人高估计 GFR (eGFR) 与动脉僵硬度之间的关联。方法：我们对 9136 名没有慢性肾脏病的中国成年人进行了一项横断面研究。动脉僵硬度通过臂踝脉搏波速度（baPWV）和脉压（PP）来测量。我们根据 eGFR 的年龄特定四分位数将参与者分为四组。肾超滤（RHF）是用 eGFR 的最高年龄特定四分位来定义的。使用多元逻辑回归模型估计升高的 baPWV 和 PP 的比值比 (OR)，并使用患有或不患有 RHF 的参与者之间的倾向评分匹配分析进行进一步测试。结果：在年龄调整模型中，RHF 与 baPWV 和 PP 升高的风险分别增加 11% 和 32%，P = 0.35 和 0.005。调整协变量后，RHF 与 baPWV 和 PP 升高的风险增加 23% 和 39% 显着相关，P = 0.01 和 0.001。这些关联在倾向评分匹配分析中得到了进一步证实。调整后的 OR（95% 置信区间）对于 baPWV 升高为 1.17（1.03-1.30），对于 PP 升高为 1.28（1.13-1.46），P = 0.02 和 P 值小于 0.001。结论：RHF 与 baPWV 和 PP 升高相关，表明 RHF 可能是检测动脉僵硬度的早期指标。
Objectives: Decreased glomerular filtration rate (GFR) has been suspected as a risk factor for arterial stiffness. Whether high GFR is the risk factor of arterial stiffness and cardiovascular disease remains uncertain. We aim to evaluate the association between high estimated GFR (eGFR) and arterial stiffness in Chinese adults. Methods: We performed a cross-sectional study involving 9136 Chinese adults without chronic kidney disease. Arterial stiffness was measured by brachial–ankle pulse wave velocity (baPWV) and pulse pressure (PP). We divided participants into four groups according to age-specific quartiles of eGFR. Renal hyperfiltration (RHF) was defined with the highest age-specific quartile of eGFR. The odds ratios (ORs) of elevated baPWV and PP were estimated using multivariate logistic regression models and were further tested using propensity score matching analysis between participants with or without RHF. Results: RHF was associated with 11 and 32% higher risk of elevated baPWV and PP in age-adjusted models, P = 0.35 and 0.005, respectively. After adjusting for covariates, RHF was significantly associated with 23 and 39% increased risk of elevated baPWV and PP, P = 0.01 and 0.001, respectively. These associations were further confirmed in propensity score matching analysis. The adjusted ORs (95% confidence interval) were 1.17 (1.03–1.30) for elevated baPWV and 1.28 (1.13–1.46) for elevated PP, P = 0.02 and P value less than 0.001, respectively. Conclusion: RHF was associated with elevated baPWV and PP, suggesting that RHF might be an early indicator for the detection of arterial stiffness.