ACTIVATION OF THE MAP KINASE HOMOLOG RK REQUIRES THE PHOSPHORYLATION OF THR-180 AND TYR-182 AND BOTH RESIDUES ARE PHOSPHORYLATED IN CHEMICALLY STRESSED KB CELLS
ACTIVATION OF THE MAP KINASE HOMOLOG RK REQUIRES THE PHOSPHORYLATION OF THR-180 AND TYR-182 AND BOTH RESIDUES ARE PHOSPHORYLATED IN CHEMICALLY STRESSED KB CELLS
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DOI：
10.1016/0014-5793(95)00346-b
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发表时间：
1995-05-08
期刊：
影响因子：
3.5
通讯作者：
NEBREDA, AR
中科院分区：
文献类型：
--
作者：
DOZA, YN;CUENDA, A;NEBREDA, AR
MAP激酶同源物，称为再活化激酶（RK），存在于介导细胞对应激反应的信号传导途径中。本文证明，在人KB细胞中，应激诱导的RK活化伴随着Thr-180和Tyr-182的磷酸化，并且这两个残基的磷酸化是该酶活化所必需的。
A MAP kinase homologue, termed the reactivating kinase (RK), lies in a signalling pathway which mediates cellular responses to stress, Here vue demonstrate that the stress-induced activation of the RK in human KB cells is accompanied by the phosphorylation of Thr-180 and Tyr-182, and that the phosphorylation of both residues is required for the activation of this enzyme.