Perirhinal N-methyl-D-aspartate and muscarinic systems participate in object recognition in rats
Perirhinal N-methyl-D-aspartate and muscarinic systems participate in object recognition in rats
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DOI：
10.1016/j.neulet.2003.11.049
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发表时间：
2004-02-19
影响因子：
2.5
通讯作者：
Iwasaki, T
中科院分区：
文献类型：
--
作者：
Abe, H;Ishida, Y;Iwasaki, T
为探讨N-甲基-D-天冬氨酸（NMDA）和毒蕈碱激活嗅周皮层在物体识别中的可能作用，将NMDA拮抗剂（D，L-2-氨基-5-磷酸戊酸（AP 5））和毒蕈碱拮抗剂（东莨菪碱）注射到大鼠嗅周皮层。高剂量的AP 5（60 mM）和两个剂量的东莨菪碱（20和80 mM），但不是单独的低剂量的AP 5（30 mM），显着受损的区分之间的新的和熟悉的对象在一个自发的对象识别任务，这是识别记忆任务之一。这些结果表明，NMDA和毒蕈碱受体在嗅周皮层的激活有助于物体识别。(C)2003爱思唯尔爱尔兰有限公司保留所有权利。
To determine the possible involvement of N-methyl-D-aspartate (NMDA) and muscarinic activation of the perirhinal cortex in object recognition, an NMDA antagonist (D,L-2-amino-5-phosphonopentanoic acid (AP5)) and a muscarinic antagonist (scopolamine) were injected into the perirhinal cortex of rats. A high dose of AP5 (60 mM) and two doses of scopolamine (20 and 80 mM), but not a low dose of AP5 (30 mM) alone, significantly impaired discrimination between novel and familiar objects in a spontaneous object recognition task, which is one of the recognition memory tasks. These results suggest that activation of both NMDA and muscarinic receptors in the perirhinal cortex contributes to object recognition. (C) 2003 Elsevier Ireland Ltd. All rights reserved.