Abscinazole-F1, a conformationally restricted analogue of the plant growth retardant uniconazole and an inhibitor of ABA 8′-hydroxylase CYP707A with no growth-retardant effect
Abscinazole-F1, a conformationally restricted analogue of the plant growth retardant uniconazole and an inhibitor of ABA 8′-hydroxylase CYP707A with no growth-retardant effect
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DOI：
10.1016/j.bmc.2009.07.070
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发表时间：
2009-09-15
影响因子：
3.5
通讯作者：
Hirai, Nobuhiro
中科院分区：
文献类型：
--
作者：
Todoroki, Yasushi;Kobayashi, Kyotaro;Hirai, Nobuhiro
脱落酸(ABA)8‘-羟基酶是脱落酸(ABA)分解代谢的关键酶，而脱落酸(ABA)8’-羟基酶是一种参与抗逆性、种子休眠等多种生理事件的植物激素。为了开发一种特异的脱落酸(ABA)8‘-羟基酶抑制剂，我们设计并合成了构象受限的烯效唑(UNI)类似物。虽然大多数类似物对ABA 8‘-羟基酶和水稻幼苗生长的抑制效果不如UNI，但我们发现含咪唑的乳糖醇桥联类似物对ABA 8’-羟基酶有很强的抑制作用，但对植物生长没有抑制作用。这种名为阿西西唑-F1的化合物，在10亩M溶液喷雾处理后，能诱导苹果幼苗耐旱。(C)2009爱思唯尔有限公司。保留所有权利。
To develop a specific inhibitor of abscisic acid (ABA) 8'-hydroxylase, a key enzyme in the catabolism of ABA, a plant hormone involved in stress tolerance, seed dormancy, and other various physiological events, we designed and synthesized conformationally restricted analogues of uniconazole (UNI), a well-known plant growth retardant, which inhibits a biosynthetic enzyme (ent-kaurene oxidase) of gibberellin as well as ABA 8'-hydroxylase. Although most of these analogues were less effective than UNI in inhibition of ABA 8'-hydroxylase and rice seedling growth, we found that a lactol-bridged analogue with an imidazole is a potent inhibitor of ABA 8'-hydroxylase but not of plant growth. This compound, abscinazole-F1, induced drought tolerance in apple seedlings upon spray treatment with a 10 mu M solution. (C) 2009 Elsevier Ltd. All rights reserved.