Influence of mode of contraction on the mechanism of acetylcholine-mediated relaxation of coronary arteries from normotensive and spontaneously hypertensive rats
Influence of mode of contraction on the mechanism of acetylcholine-mediated relaxation of coronary arteries from normotensive and spontaneously hypertensive rats
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DOI：
10.1042/cs0940231
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发表时间：
1998-03-01
期刊：
影响因子：
6
通讯作者：
Bund, SJ
中科院分区：
文献类型：
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作者：
Bund, SJ
1、比较20周龄自发性高血压大鼠(SHR)和正常血压大鼠(WKY)在加压无血流条件下血管内皮依赖性乙酰胆碱介导的小冠状动脉(内径约200微米)的松弛。(2)模拟血栓素A的U46619收缩后，WKY和自发性高血压大鼠的小冠状动脉(WKY)和自发性高血压大鼠(WKY)在产生肌张力后的松弛没有差别，吲哚美辛(10MU/L)或联合N-奥米伽-硝基-L精氨酸(L-NNA，0.1 mmol/L)，对两者的松弛没有显著影响。30 mmoL/L K+可显著减弱SHR的最大松弛，由85+/-7%(n=11)减弱至20+/-8%(n=8)，P
1, Endothelium-dependent acetylcholine-mediated relaxations of small coronary arteries (similar to 200 mu m internal diameter) from 20 weeks old spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) controls were compared under pressurized no-flow conditions after the development of myogenic tone or constriction with the thromboxane A(2) mimetic U46619,2, Relaxations of WKY and SHR arteries following development of myogenic tone did not differ and were not significantly influenced by indomethacin alone (10 mu mol/l) or in combination with N-omega-nitro-L-arginine (L-NNA, 0.1 mmol/l), Maximum relaxations were significantly attenuated by 30 mmol/l K+ in the SHR, from 85+/-7% (n=11) to 20+/-8% (n = 8), P