Humoral and Cellular Immunity Changed after Traumatic Brain Injury in Human Patients.
Humoral and Cellular Immunity Changed after Traumatic Brain Injury in Human Patients.
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人类患者脑外伤后体液和细胞免疫发生变化。
DOI：
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Zhao Qi-Huang
中科院分区：
文献类型：
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作者：
Wang Jia-Wei;Li Jin-Ping;Song Ying-Lun;Zhao Qi-Huang
先前的研究表明，创伤性脑损伤（TBI）后感染的风险明显较高。这种感染倾向可能是由TBI后免疫系统中的脑特异性反应引起的。然而，目前缺乏充分描述TBI患者特征的研究，以了解TBI与外周免疫功能之间的关系。在本研究中，体液免疫和细胞免疫的标记物进行了测量长达2周的外周血中的37例TBI患者，以阐明TBI后的外周免疫反应的时间过程和类型。对照组为12例无脑外伤及其他神经系统疾病的相对健康者。我们的数据表明，TBI可诱导体液免疫的显着变化，其特征是IgG和IgM水平下降，补体C3和C4水平升高，与对照组相比。此外，与对照组相比，外周血CD 3+和CD 3 + CD 4+淋巴细胞计数在创伤发生后早期（1-3天）出现显著降低。这些结果提供了证据表明，TBI与体液免疫和细胞免疫的实质性变化有关，这可能解释了这些患者感染的高发病率。
Previous studies have suggested that there is a disproportionally higher risk of infection following traumatic brain injury (TBI). This predisposition to infection may be driven by a poorly understood, brain-specific response in the immune system after TBI. However, there is a lack of studies that have fully characterized TBI patients to understand the relationship between TBI and peripheral immune function. In the present study, markers for humoral immunity and cellular immunity were measured for up to 2 weeks in the peripheral blood of 37 patients with TBI in order to elucidate the time course and the type of the peripheral immune response following TBI. 12 relatively healthy individuals without TBI and other neurological diseases were enrolled into the control group. Our data indicated that TBI could induce significant changes in humoral immunity characterized by a decrease in IgG and IgM levels and an increase in the complements C3 and C4 levels in comparison with the control group. Moreover, compared with the control group, a significant reduction in peripheral blood CD3+ and CD3+CD4+ lymphocyte counts occurred early (days 1-3) following the onset of trauma. These results provide evidence that TBI is associated with substantial changes in humoral immunity and cellular immunity, which may explain the high incidence of infection encountered in these patients.