A PROSPECTIVE-STUDY OF POSTMENOPAUSAL ESTROGEN THERAPY AND CORONARY HEART-DISEASE
A PROSPECTIVE-STUDY OF POSTMENOPAUSAL ESTROGEN THERAPY AND CORONARY HEART-DISEASE
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DOI：
10.1056/nejm198510243131703
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发表时间：
1985-01-01
影响因子：
158.5
通讯作者：
HENNEKENS, CH
中科院分区：
文献类型：
--
作者：
STAMPFER, MJ;WILLETT, WC;HENNEKENS, CH
To clarify the possible role of postmenopausal estrogen use in coronary heart disease, we surveyed 121,964 female nurses, aged 30 to 55 years, with mailed questionnaires, beginning in 1976. Information on hormone use and other potential risk factors was updated and the incidence of coronary heart disease was ascertained through additional questionnaires in 1978 and 1980, with a 92.7 percent follow-up.终点由医疗记录记录。 During 105,786 person-years of observation among 32,317 postmenopausal women who were initially free of coronary disease, 90 women had either nonfatal myocardial infarctions (65 cases) or fatal coronary heart disease (25 cases). As compared with the risk in women who had never used postmenopausal hormones, the age-adjusted relative risk of coronary disease in those who had ever used them was 0.5 (95 percent confidence limits, 0.3 and 0.8; P = 0.007), and the risk in current users was 0.3 (95 percent confidence limits, 0.2 and 0.6; P = 0.001). The relative risks were similar for fatal and nonfatal disease and were unaltered after adjustment for cigarette smoking, hypertension, diabetes, high cholesterol levels, a parental history of myocardial infarction, past use of oral contraceptives, and obesity.这些数据支持这样的假设：绝经后使用雌激素可降低严重冠心病的风险。
To clarify the possible role of postmenopausal estrogen use in coronary heart disease, we surveyed 121,964 female nurses, aged 30 to 55 years, with mailed questionnaires, beginning in 1976. Information on hormone use and other potential risk factors was updated and the incidence of coronary heart disease was ascertained through additional questionnaires in 1978 and 1980, with a 92.7 percent follow-up. End points were documented by medical records. During 105,786 person-years of observation among 32,317 postmenopausal women who were initially free of coronary disease, 90 women had either nonfatal myocardial infarctions (65 cases) or fatal coronary heart disease (25 cases). As compared with the risk in women who had never used postmenopausal hormones, the age-adjusted relative risk of coronary disease in those who had ever used them was 0.5 (95 percent confidence limits, 0.3 and 0.8; P = 0.007), and the risk in current users was 0.3 (95 percent confidence limits, 0.2 and 0.6; P = 0.001). The relative risks were similar for fatal and nonfatal disease and were unaltered after adjustment for cigarette smoking, hypertension, diabetes, high cholesterol levels, a parental history of myocardial infarction, past use of oral contraceptives, and obesity. These data support the hypothesis that the postmenopausal use of estrogen reduces the risk of severe coronary heart disease.