FXR1a-associated microRNP: A driver of specialized non-canonical translation in quiescent conditions
FXR1a-associated microRNP: A driver of specialized non-canonical translation in quiescent conditions
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DOI：
10.1080/15476286.2016.1265197
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发表时间：
2017-01-01
期刊：
影响因子：
4.1
通讯作者：
Vasudevan, Shobha
中科院分区：
文献类型：
--
作者：
Bukhari, Syed I. A.;Vasudevan, Shobha
真核蛋白质合成是一个多方面的过程，需要在特定的细胞状态下协调一组翻译因子。在正常生长和增殖过程中，细胞通常通过利用经典翻译因子的常规翻译来制造它们的蛋白质组。当面临环境压力（如生长因子剥夺）或对生物学线索（如发育信号）作出反应时，细胞可以减少规范翻译。在这种情况下，细胞适应替代的翻译模式，以使特定的蛋白质在这些不同的条件下所需的生物功能。迄今为止，已经报道了许多替代翻译机制，包括非规范的、帽依赖性翻译和帽非依赖性翻译，如IRES介导的翻译。在这里，我们讨论了一种由专门的microRNA复合物介导的替代翻译模式之一，FXR 1a-microRNP，它在静止条件下促进非规范的帽依赖性翻译，其中规范翻译由于低mTOR活性而减少。
Eukaryotic protein synthesis is a multifaceted process that requires coordination of a set of translation factors in a particular cellular state. During normal growth and proliferation, cells generally make their proteome via conventional translation that utilizes canonical translation factors. When faced with environmental stress such as growth factor deprivation, or in response to biological cues such as developmental signals, cells can reduce canonical translation. In this situation, cells adapt alternative modes of translation to make specific proteins necessary for required biological functions under these distinct conditions. To date, a number of alternative translation mechanisms have been reported, which include non-canonical, cap dependent translation and cap independent translation such as IRES mediated translation. Here, we discuss one of the alternative modes of translation mediated by a specialized microRNA complex, FXR1a-microRNP that promotes non-canonical, cap dependent translation in quiescent conditions, where canonical translation is reduced due to low mTOR activity.