Benefits for Type 2 Diabetes of Interrupting Prolonged Sitting With Brief Bouts of Light Walking or Simple Resistance Activities
Benefits for Type 2 Diabetes of Interrupting Prolonged Sitting With Brief Bouts of Light Walking or Simple Resistance Activities
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DOI：
10.2337/dc15-2336
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发表时间：
2016-06-01
期刊：
影响因子：
16.2
通讯作者：
Dunstan, David W.
中科院分区：
文献类型：
--
作者：
Dempsey, Paddy C.;Larsen, Robyn N.;Dunstan, David W.
为了确定是否中断长时间坐着与短暂的小强度步行（LW）或简单的阻力活动（SRA），改善餐后心血管代谢的风险标志物在成人2型糖尿病（T2 D）。24例不活动的超重/肥胖T2 D成人14例62 ~ 6岁男性在3天内接受了以下8小时条件（洗脱期为6-14天）：不间断坐位（对照）（SIT），坐位+3分钟LW发作（3.2 km h（-1）），每30分钟一次，坐着加3分钟的SRA（半蹲，小腿抬起，臀部收缩，膝盖抬起）每30分钟。在每种情况下消耗标准化的膳食。比较不同条件下葡萄糖、胰岛素、C肽和甘油三酯的曲线下面积（iAUC）的增加。（SIT平均值24.2 mmol h L-1 [95% CI 20.4-28.0] vs. LW 14.8 [11.0-18.6]和SRA 14.7 [10.9-18.5]），胰岛素（SIT 3，293 pmol hL（-1）[2，887 - 3，700] vs. LW 2，104 [1，696 - 2，511]和SRA 2，066 [1，660 - 2，473]）和C肽（SIT 15，641 pmol h L-1 [14，353 - 16，929] vs. LW 11，504 [10，209 - 12，799]和SRA 11，012 [9，723 - 12，301]）（所有P < 0.001）。SRA的甘油三酯iAUC显著减弱（P < 0.001），但LW无（SIT 4.8 mmol h L-1 [3.6-6.0] vs. LW 4.0 [2.8-5.1]和SRA 2.9 [1.7-4.1]）。结论：用短暂的LW或SRA中断长时间静坐可降低急性餐后血糖、胰岛素、C肽、和甘油三酯反应。由于对结构化锻炼的坚持性较差，这种方法可能是有益和实用的。
OBJECTIVETo determine whether interrupting prolonged sitting with brief bouts of light-intensity walking (LW) or simple resistance activities (SRA) improves postprandial cardiometabolic risk markers in adults with type 2 diabetes (T2D).RESEARCH DESIGN AND METHODSIn a randomized crossover trial, 24 inactive overweight/obese adults with T2D (14 men 62 6 years old) underwent the following 8-h conditions on three separate days (with 6-14 days washout): uninterrupted sitting (control) (SIT), sitting plus 3-min bouts of LW (3.2 km h(-1)) every 30 min, and sitting plus 3-min bouts of SRA (half-squats, calf raises, gluteal contractions, and knee raises) every 30 min. Standardized meals were consumed during each condition. Incremental areas under the curve (iAUCs) for glucose, insulin, C-peptide, and triglycerides were compared between conditions.RESULTSCompared with SIT, both activity-break conditions significantly attenuated iAUCs for glucose (SIT mean 24.2 mmol h L-1 [95% CI 20.4-28.0] vs. LW 14.8 [11.0-18.6] and SRA 14.7 [10.9-18.5]), insulin (SIT 3,293 pmol hL(-1) [2,887-3,700] vs. LW 2,104 [1,696-2,511] and SRA 2,066 [1,660-2,473]), and C-peptide (SIT 15,641 pmol h L-1 [14,353-16,929] vs. LW 11,504 [10,209-12,799] and SRA 11,012 [9,723-12,301]) (all P < 0.001). The iAUC for triglycerides was significantly attenuated for SRA (P < 0.001) but not for LW (SIT 4.8 mmol h L-1 [3.6-6.0] vs. LW 4.0 [2.8-5.1] and SRA 2.9 [1.7-4.1]).CONCLUSIONSInterrupting prolonged sitting with brief bouts of LW or SRA attenuates acute postprandial glucose, insulin, C-peptide, and triglyceride responses in adults with T2D. With poor adherence to structured exercise, this approach is potentially beneficial and practical.