IL-1β in eosinophil-mediated small intestinal homeostasis and IgA production.
IL-1β in eosinophil-mediated small intestinal homeostasis and IgA production.
复制标题
嗜酸性粒细胞介导的小肠稳态和IgA产生中的IL-1β。
作者：
嗜酸性粒细胞是存在于胃肠道（GI）固有层中的多功能白细胞，其基础功能在很大程度上尚未探索。在这项研究中，通过检查全身嗜酸性粒细胞（通过谱系消融）或GI嗜酸性粒细胞（嗜酸性粒细胞趋化因子-1/2双缺陷或CC趋化因子受体3缺陷）的选择性缺陷的小鼠，我们表明嗜酸性粒细胞支持免疫球蛋白A（伊加）类别转换，维持肠道粘液分泌，影响肠道微生物组成，并促进派尔集合淋巴结的发展。嗜酸性粒细胞缺陷小鼠表现出分泌型伊加产生介质的表达减少，包括肠白细胞介素1β（IL-1β）、诱导型一氧化氮合酶、光敏素（LT）α和LT-β，以及维甲酸相关孤儿受体γ t阳性（ROR-γt+）先天淋巴细胞（ILC）水平降低，同时维持正常的APRIL水平。（增殖诱导配体）、BAFF（肿瘤坏死因子家族的B细胞活化因子）和TGF-β（转化生长因子β）。GI嗜酸性粒细胞表达相对较高水平的IL-1β，IL-1β缺乏小鼠表现出嗜酸性粒细胞缺乏小鼠中观察到的基因表达谱改变，伊加+细胞和ROR-γt+ ILC水平降低。基于这些收集的数据，我们提出嗜酸性粒细胞是稳态肠道免疫应答（包括伊加产生）所必需的，并且它们的作用是通过小肠中的IL-1β介导的。
Eosinophils are multifunctional leukocytes that reside in the gastrointestinal (GI) lamina propria, where their basal function remains largely unexplored. In this study, by examining mice with a selective deficiency of systemic eosinophils (by lineage ablation) or GI eosinophils (eotaxin-1/2 double–deficient or CC chemokine receptor 3–deficient), we show that eosinophils support immunoglobulin A (IgA) class switching, maintain intestinal mucus secretions, affect intestinal microbial composition, and promote the development of Peyer’s patches. Eosinophil-deficient mice showed reduced expression of mediators of secretory IgA production, including intestinal interleukin 1β (IL-1β), inducible nitric oxide synthase, lymphotoxin (LT) α, and LT-β, and reduced levels of retinoic acid-related orphan receptor gamma t–positive (ROR-γt+) innate lymphoid cells (ILCs) while maintaining normal levels of APRIL (a proliferation-inducing ligand), BAFF (B cell–activating factor of the tumor necrosis factor family), and TGF-β (transforming growth factor β). GI eosinophils expressed a relatively high level of IL-1β, and IL-1β–deficient mice manifested the altered gene expression profiles observed in eosinophil-deficient mice and decreased levels of IgA+ cells and ROR-γt+ ILCs. On the basis of these collective data, we propose that eosinophils are required for homeostatic intestinal immune responses including IgA production and that their affect is mediated via IL-1β in the small intestine.
登录
查看更多内容
TACI和BAFF-R介导B细胞中的同种型切换。
影响因子：
15.3
作者：
Castigli, E;Wilson, SA;Scott, S;Dedeoglu, F;Xu, SL;Lam, KP;Bram, RJ;Jabara, H;Geha, RS
通讯作者：
Geha, RS
影响因子：
64.8
作者：
Fritz, Joerg H.;Rojas, Olga Lucia;Simard, Nathalie;McCarthy, Douglas D.;Hapfelmeier, Siegfried;Rubino, Stephen;Robertson, Susan J.;Larijani, Mani;Gosselin, Jean;Ivanov, Ivaylo I.;Martin, Alberto;Casellas, Rafael;Philpott, Dana J.;Girardin, Stephen E.;McCoy, Kathy D.;Macpherson, Andrew J.;Paige, Christopher J.;Gommerman, Jennifer L.
通讯作者：
Gommerman, Jennifer L.
胃肠道嗜酸性粒细胞在免疫和疾病中的作用和调节。
DOI：
10.4049/jimmunol.1400413
发表时间：
2014-08-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Jung Y;Rothenberg ME
通讯作者：
Rothenberg ME
影响因子：
32.4
作者：
Hughes T;Becknell B;Freud AG;McClory S;Briercheck E;Yu J;Mao C;Giovenzana C;Nuovo G;Wei L;Zhang X;Gavrilin MA;Wewers MD;Caligiuri MA
通讯作者：
Caligiuri MA
DOI：
10.1084/jem.20011910
发表时间：
2002-01-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Lamm ME;Phillips-Quagliata JM
通讯作者：
Phillips-Quagliata JM