Are iodinated contrast agents detrimental in acute cerebral ischemia? An experimental study in rats.
Are iodinated contrast agents detrimental in acute cerebral ischemia? An experimental study in rats.
复制标题
碘造影剂对急性脑缺血有害吗？
作者：
A. Doerfler;T. Engelhorn;R. von Kummer;J. Weber;M. Knauth;S. Heiland;K. Sartor;M. Forsting
目的
目的 研究碘酞酸钠和两种剂量的碘普罗胺治疗急性脑缺血对大脑中动脉闭塞大鼠模型梗塞体积、神经功能和死亡率的影响。
材料和方法
六十四只大鼠接受了大脑中动脉的血管内闭塞。四小时后，16只动物接受碘酞酸钠（每公斤588毫克碘）； 16、碘普罗胺单次推注（每公斤518毫克碘）； 16、碘普罗胺双份推注（每公斤 1,036 毫克碘）。十六只动物接受等体积的盐水（对照组）。每8小时记录一次神经系统评分和体重。闭塞后二十四小时，处死所有动物；对大脑进行染色以评估梗塞的大小。
结果
单剂量和双剂量的碘普罗胺不影响梗塞体积或神经功能。碘酞酸盐导致梗塞体积增加和神经系统评分恶化 (p < .05)。碘酞胺组的死亡率为 25%，对照组为 12%，碘普罗胺组为 6%。
结论
推注非离子碘普罗胺对梗塞体积或脑缺血症状没有统计学上的显着影响。急性脑缺血期间应首选非离子造影剂而不是离子造影剂。
PURPOSE
To study the effects of iothalamate sodium and two dosages of iopromide in acute cerebral ischemia on infarction volume, neurologic performance, and mortality in a rat model of middle cerebral artery occlusion.
MATERIALS AND METHODS
Sixty-four rats underwent endovascular occlusion of the middle cerebral artery. Four hours later, 16 animals received iothalamate sodium (588 mg iodine per kilogram); 16, iopromide as a single bolus (518 mg iodine per kilogram); and 16, iopromide as a double bolus (1,036 mg iodine per kilogram). Sixteen animals received equivolumetric saline (control group). Neurologic score and body weight were recorded every 8 hours. Twenty-four hours after occlusion, all animals were killed; brains were stained to assess the infarction size.
RESULTS
Single and double doses of iopromide did not affect infarction volume or neurologic performance. Iothalamate caused an increase in infarction volume and worsening of the neurologic score (p < .05). Mortality rate was 25% in the iothalamate group, 12% in the control group, and 6% in the iopromide groups.
CONCLUSION
Bolus injection of the nonionic iopromide does not statistically significantly affect infarction volume or cerebral ischemia symptoms. Nonionic rather than ionic contrast agents should be preferred during acute cerebral ischemia.