Chronic treatment with losartan and carvedilol differentially modulates renal vascular responses to sympathomimetics compared to treatment with individual agents in normal Wistar Kyoto and spontaneously hypertensive rats
Chronic treatment with losartan and carvedilol differentially modulates renal vascular responses to sympathomimetics compared to treatment with individual agents in normal Wistar Kyoto and spontaneously hypertensive rats
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DOI：
10.1016/j.ejphar.2009.03.064
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发表时间：
2009-06-10
影响因子：
5
通讯作者：
Johns, Edward J.
中科院分区：
文献类型：
--
作者：
Abdulla, Mohammed H.;Sattar, Munavvar A.;Johns, Edward J.
本研究旨在研究血管紧张素II和肾上腺素受体慢性累积阻断对WKY和SHR的影响，并探讨肾血管对肾上腺素和血管紧张素II受体激动剂的反应是如何相互依赖的。大鼠分别给予氯沙坦、卡维地洛或氯沙坦+卡维地洛治疗7 d，第8天给予戊巴比酮麻醉，准备肾血流动力学研究。剂量-反应关系是根据肾动脉注射多巴胺、苯肾上腺素和异丙肾上腺素后肾血流量大小的降低/升高来确定的。与未治疗的对照组相比，氯沙坦或卡维地洛治疗的WKY和SHR患者肾血管反应减弱
This study set out to investigate the impact of chronic cumulative blockade of angiotensin II and adrenoceptors in WKY and SHR and to explore how the renovascular responses to adrenergic and angiotensin II receptor agonists may be interdependent. Rats were treated with either losartan, carvedilol or losartan + carvedilol for 7 days and on day eight, animals were pentobarbitone anaesthetized and prepared for renal haemodynamic study. Dose-response relationships were determined in terms of reduction/elevation in the magnitude of renal blood flow in response to intrarenal arterial injection of dopamine, phenylephrine and isoprenaline. Renal vascular responses were blunted in WKY and SHR treated with either losartan or carvedilol as compared to their untreated counterparts (P