The free-to-total serum prostate specific antigen ratio for staging prostate carcinoma
The free-to-total serum prostate specific antigen ratio for staging prostate carcinoma
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DOI：
10.1016/s0022-5347(01)65197-8
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发表时间：
1997-02-01
影响因子：
6.6
通讯作者：
Schroder, FH
中科院分区：
文献类型：
--
作者：
Bangma, CH;Kranse, R;Schroder, FH
目的：材料与方法：对123例前列腺癌患者的血清总PSA、血清游离PSA/总PSA比值与前列腺癌临床分期、病理分级及临床分期进行相关性分析。血清总PSA和游离PSA/总PSA比值在良性与恶性疾病（任何分期）之间以及任何T分类与淋巴结疾病之间的分布差异均有统计学意义。对于血清PSA显着差异之间的分布与局部局限性（T1和T2阶段）和局部扩展（T3阶段）的疾病，并在所有的T类和全身转移性疾病。这一发现是没有注意到的游离总PSA ratio.Conclusions：游离总PSA的比率相比，血清PSA在前列腺癌的临床分期没有额外的价值。游离PSA与总PSA的比率可以被认为是细胞分化的结果，而不是肿瘤负荷的指标。
Purpose: We analyzed the relationship between the free-to-total PSA ratio and prostate cancer tumor stage and grade compared to total serum PSA.Materials and Methods: In 123 patients clinical and pathological grade and stage were related to total serum PSA and free-to-total PSA ratio.Results: Total serum PSA paralleled clinical staging of prostate cancer. The distributions of total serum PSA and the free-to-total PSA ratio were significantly different between benign and malignant diseases (any stage), and between any T category and nodal disease. For serum PSA significant differences were noted between the distributions of men with locally confined (stages T1 and T2) and locally extended (stage T3) disease, and between all T categories and systemic metastatic disease. This finding was not noted for the free-to-total PSA ratio.Conclusions: The free-to-total PSA ratio has no additional value in clinical staging of prostate carcinoma compared to serum PSA. The free-to-total PSA ratio may be considered the result of cell differentiation and not an indicator of tumor load.