CONTROL OF CELL FATES IN THE CENTRAL BODY REGION OF C-ELEGANS BY THE HOMEOBOX GENE LIN-39
CONTROL OF CELL FATES IN THE CENTRAL BODY REGION OF C-ELEGANS BY THE HOMEOBOX GENE LIN-39
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DOI：
10.1016/0092-8674(93)90293-y
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发表时间：
1993-07-16
期刊：
影响因子：
64.5
通讯作者：
HORVITZ, HR
中科院分区：
文献类型：
--
作者：
CLARK, SG;CHISHOLM, AD;HORVITZ, HR
线虫C.秀丽线虫的发育与它们的前部或后部同源物不同。lin-39基因是身体中部特定区域发育所必需的。在lin-39突变体中，中间体细胞表达更多前部或后部同源物的特征性命运，并且成神经细胞通过中间体的迁移是有缺陷的。lin-39在这些中间体细胞和迁移的成神经细胞中自主地起细胞作用。lin-39编码一种具有果蝇类同源结构域的蛋白质，与果蝇同源异型基因Deformed和Sex combs reduced的同源异型结构域最相似，并且与另外两个区域同源异型基因mab-5和egl-5位于同源异型基因簇中。lin-39和mAb-5在2个外胚层细胞中组合发挥作用，并且在性腺发育中具有冗余功能。
Cells in the mid-body region of the nematode C. elegans develop differently from their anterior or posterior homologs. The gene lin-39 is required for mid-body region-specific development. In lin-39 mutants, midbody cells express fates characteristic of more anterior or posterior homologs, and the migration of a neuroblast through the mid-body is defective. lin-39 acts cell autonomously in these mid-body cells and in the migrating neuroblast. lin-39 encodes a protein with an Antennapedia class homeodomain, most similar to those of the Drosophila homeotic genes Deformed and Sex combs reduced, and is located in a homeotic gene cluster with two other regional homeotic genes, mab-5 and egl-5. lin-39 and mab-5 function combinatorially in 2 ectodermal cells and have redundant functions in gonad development.