Behavior-dependent states of the hippocampal network affect functional clustering of neurons
Behavior-dependent states of the hippocampal network affect functional clustering of neurons
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DOI：
10.1523/jneurosci.21-10-j0003.2001
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发表时间：
2001-05-15
影响因子：
5.3
通讯作者：
Buzsáki, G
中科院分区：
文献类型：
--
作者：
Hirase, H;Leinekugel, X;Buzsáki, G
本实验观察了行为大鼠海马CA 1区锥体细胞的局部与远距离相干性。锥体细胞的时间交叉相关性揭示了一个显着更强的关系，在非θ相关的不动和睡眠，但不是在θ相关的运行和行走的本地（300妈妈）神经元。与此相反，当地的锥体细胞-中间神经元对之间的交叉相关性显着强于远距离之间的对在θ振荡，但在非θ相关的行为是相似的。我们认为，网络状态依赖的神经元活动的功能聚类出现，因为主要的兴奋性输入，perforant路径，和谢弗侧支在θ和非θ行为的差异贡献。
Local versus distant coherence of hippocampal CA1 pyramidal cells was investigated in the behaving rat. Temporal cross-correlation of pyramidal cells revealed a significantly stronger relationship among local (300 mum) neurons during non-theta-associated immobility and sleep but not during theta-associated running and walking. In contrast, cross-correlation between local pyramidal cell-interneuron pairs was significantly stronger than between distant pairs during theta oscillations but were similar during non-theta-associated behaviors. We suggest that network state-dependent functional clustering of neuronal activity emerges because of the differential contribution of the main excitatory inputs, the perforant path, and Schaffer collaterals during theta and non-theta behaviors.