Cognitive functioning in treatment-seeking Gulf War veterans: Pyridostigmine bromide use and PTSD
Cognitive functioning in treatment-seeking Gulf War veterans: Pyridostigmine bromide use and PTSD
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DOI：
10.1023/a:1023342915425
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发表时间：
2003-06-01
影响因子：
1.6
通讯作者：
White, RF
中科院分区：
文献类型：
--
作者：
Sullivan, K;Krengel, M;White, RF
海湾战争（GW）的退伍军人报告说，从战争回来后出现了中枢神经系统（CNS）功能障碍的健康症状。这些症状包括记忆力和注意力难以集中、疲劳和头痛。这些认知疾病病因的主要假设包括心理因素和/或暴露于具有神经毒性的化学物质。在本研究中，比较了寻求治疗的gw部署退伍军人和寻求治疗的非gw部署退伍军人对照组的认知功能。结果表明，在注意力、视觉空间技能、视觉记忆和情绪测试中，退伍军人的表现明显差于对照组。报告服用吡哆斯的明（PB）的gw部署退伍军人在执行系统任务上的表现比未使用PB的gw部署退伍军人差。诊断为创伤后应激障碍（PTSD）的退伍军人在认知测试中与没有创伤后应激障碍的退伍军人相比，寻求治疗的退伍军人在认知测试中没有差异。PTSD与PB使用无交互作用。
Gulf War (GW) deployed veterans have reported health symptoms since returning from the war that suggest dysfunction of the central nervous system (CNS). These symptoms include memory and concentration difficulties, fatigue, and headaches. Leading hypotheses for the etiology of these cognitive complaints include psychological factors and/or exposures to chemicals with neurotoxic properties. In this study, cognitive functioning was compared in treatment-seeking GW-deployed veterans and a treatment-seeking non-GW-deployed veteran control group. Results indicated that GW-deployed veterans performed significantly worse than the comparison group on tests of attention, visuospatial skills, visual memory, and mood. GW-deployed veterans who reported taking pyridostigmine bromide (PB) performed worse than GW-deployed veterans without PB use on executive system tasks. Treatment-seeking GW-deployed veterans with diagnoses of posttraumatic stress disorder (PTSD) did not differ on cognitive test measures compared with GW-deployed veterans without PTSD. No interaction effect of PTSD and PB use was found.