The IMEx Coronavirus interactome: an evolving map of Coronaviridae-Host molecular interactions.
The IMEx Coronavirus interactome: an evolving map of Coronaviridae-Host molecular interactions.
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IMEx 冠状病毒相互作用组：冠状病毒科-宿主分子相互作用的演化图谱。
DOI：
10.1101/2020.06.16.153817
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Hermjakob,
中科院分区：
文献类型：
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作者：
Perfetto,L;Pastrello,C;Del-Toro,N;Duesbury,M;Iannuccelli,M;Kotlyar,M;Licata,L;Meldal,B;Panneerselvam,K;Panni,S;Rahimzadeh,N;Ricard-Blum,S;Salwinski,L;Shrivastava,A;Cesareni,G;Pellegrini,M;Orchard,S;Jurisica,I;Hermjakob,
目前由严重急性呼吸道综合征冠状病毒（SARS-CoV）-2引起的2019冠状病毒病（COVID-19）大流行，引发了一场规模几乎前所未有的研究浪潮。在用于了解疾病和开发有效治疗方法的不同策略中，物理分子相互作用的研究可以提供病毒生物学和人类生物体反应背后机制的精细解析。我们提出了一个精心策划的物理分子相互作用的数据集，集中在蛋白质从SARS-CoV-2，SARS-CoV-1和其他成员的冠状病毒家族已手动提取的国际分子交换（IMEx）协会策展人。目前，该数据集包括从151个出版物中提取的超过4400个二进制化交互。该数据集可以在IntAct数据库网站（https：//www.ebi.ac.uk/intact）上以蛋白质组学标准倡议（HUPO-PSI）推荐的标准格式访问，并将随着COVID-19研究的进展而不断更新。
The current coronavirus disease of 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus (SARS-CoV)-2, has spurred a wave of research of nearly unprecedented scale. Among the different strategies that are being used to understand the disease and develop effective treatments, the study of physical molecular interactions can provide fine-grained resolution of the mechanisms behind the virus biology and the human organism response. We present a curated dataset of physical molecular interactions focused on proteins from SARS-CoV-2, SARS-CoV-1 and other members of theCoronaviridaefamily that has been manually extracted by International Molecular Exchange (IMEx) Consortium curators. Currently, the dataset comprises over 4400 binarized interactions extracted from 151 publications. The dataset can be accessed in the standard formats recommended by the Proteomics Standards Initiative (HUPO-PSI) at the IntAct database website (https://www.ebi.ac.uk/intact) and will be continuously updated as research on COVID-19 progresses.