Parkinsonian signs and substantia nigra neuron density in decendents elders without PD
Parkinsonian signs and substantia nigra neuron density in decendents elders without PD
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DOI：
10.1002/ana.20226
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发表时间：
2004-10-01
影响因子：
11.2
通讯作者：
White, LR
中科院分区：
文献类型：
--
作者：
Ross, GW;Petrovitch, H;White, LR
在檀香山-亚洲老龄化研究中，对217名男性参与者的单个横向尾侧中脑切片进行了黑质（SN）神经元计数，这些参与者死亡时年龄为74-97岁。用求积仪确定SN内的象限面积，并将10例帕金森病（PD）病例、29例偶发性路易体病例和178例两种疾病均无的对照者的神经元密度表示为神经元/mm（2）。PD组所有象限的平均密度均显著低于其他组（p = 0.006）。这种关系在腹外侧象限最强。在一个由50名对照者组成的亚组中，他们在死亡前平均2.1年接受了统一帕金森病评定量表的检查，（p = 0.009），姿势不稳定（p = 0.013），身体运动迟缓（p = 0.048）和步态障碍（p = 0.05）神经元密度在背外侧象限;言语障碍（p = 0.014）、面部表情异常（p = 0.022）和从椅子上起身困难（p = 0.032），神经元密度在背内侧象限。在两个象限中，存在的体征数量增加与神经元密度降低显著相关（趋势p = 0.001）。低SN神经元密度可能是无PD的老年人帕金森病体征的基础。
Substantia nigra (SN) neurons were counted on single, transverse caudal midbrain sections from 217 male participants in the Honolulu-Asia Aging Study, aged 74-97 years at death. Quadrants areas within the SN were determined with a planimeter and neuronal density was expressed as neurons/mm(2) for 10 Parkinson's disease (PD) cases, 29 incidental Lewy body cases, and 178 controls with neither condition. Mean densities in all quadrants were significantly lower in the PD group compared with the other groups (p = 0.006). This relationship was strongest in the ventrolateral quadrant. In a subgroup of 50 controls who were examined with the Unified Parkinson's Disease Rating Scale an average of 2.1 years prior to death, there was an association of stooped posture (p = 0.009), postural instability (p = 0.013), body bradykinesia (p = 0.048), and gait disturbance (p = 0.05) with neuron density in the dorsolateral quadrant; and impaired speech (p = 0.014), abnormal facial expression (p = 0.022), and difficulty rising from a chair (p = 0.032) with neuron density in the dorsomedial quadrant. There was a significant association of increasing number of signs present with decreasing neuron density in both quadrants (p = 0.001 for trend). Low SN neuron density may be the basis for parkinsonian signs in the elderly without PD.