New insecticidal rocaglamide derivatives from flowers of Aglaia duperreana (Meliaceae)
New insecticidal rocaglamide derivatives from flowers of Aglaia duperreana (Meliaceae)
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DOI：
10.1016/s0031-9422(99)00327-1
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发表时间：
1999-11-01
期刊：
影响因子：
3.8
通讯作者：
Proksch, P
中科院分区：
文献类型：
--
作者：
Chaidir;Hiort, J;Proksch, P
从越南采集的米仔兰（Aglaiaduperreana）花中分离得到13个罗格酰胺型环五氢苯并呋喃类化合物，其中5个为新的天然产物。报道了新化合物的结构鉴定及其对害虫Spodoptera littoralis的杀虫活性。大多数分离的罗格列酰胺衍生物表现出强至中等的杀虫活性。最具活性的化合物在生物活性方面与已知的天然杀虫剂印楝素相似，然而，发现在两种分离的新衍生物中存在的OC 2 H 5取代基取代C-8b处的OH基团（这是大多数已知的罗格列酰胺同系物的特征结构特征）导致杀虫活性的丧失。(C)1999 Elsevier Science Ltd.保留所有权利。
Flowers of Aglaia duperreana collected in Vietnam yielded thirteen insecticidal cyclopentatetrahydrobenzofuran derivatives of the rocaglamide type including five compounds which proved to be new natural products. Structure elucidation of the new compounds and their insecticidal activity against larvae of the pest insect Spodoptera littoralis are described. Most of the isolated rocaglamide derivatives exhibited strong to moderate insecticidal activity. The most active compounds were similar with regard to their bioactivity to the well known natural insecticide azadirachtin, However, replacement of the OH-group at C-8b (that is a characteristic structural feature of most known rocaglamide congeners) by an OC2H5-substituent as present in two of the isolated new derivatives was found to result in a loss of insecticidal activity. (C) 1999 Elsevier Science Ltd. All rights reserved.