Assessment of femoral neck bone metabolism using 18F-sodium fluoride PET/CT imaging.
Assessment of femoral neck bone metabolism using 18F-sodium fluoride PET/CT imaging.
复制标题
使用 18F-氟化钠 PET/CT 成像评估股骨颈骨代谢。
DOI：
10.1016/j.bone.2020.115351
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发表时间：
2020
期刊：
影响因子：
4.1
通讯作者：
Rajapakse,ChamithS
中科院分区：
文献类型：
--
作者：
Rhodes,Sylvia;Batzdorf,Alexandra;Sorci,Olivia;Peng,Matthew;Jankelovits,Amanda;Hornyak,Julia;An,Jongyun;Noël,PeterB;Høilund-Carlsen,PoulF;Alavi,Abass;Rajapakse,ChamithS
BackgroundStandard of care代谢性骨病评估依赖于骨量的变化，而骨量的变化只能在结构变化发生后才能检测到。PurposeTo调查骨代谢评分（BMS）的有用性，BMS来自氟18标记的氟化钠（18F-NaF）PET/CT成像，作为股骨颈局部代谢变化的生物标志物。纳入了139名接受18F-NaF PET/CT检查的参与者（68名女性和71名男性，年龄21-75岁）。BMS计算为骨区域的标准摄取值（SUV）与总区域的标准摄取值的比值。进行BMS与年龄、CT衍生骨矿物质密度（BMD）、体重指数（BMI）、身高和体重的相关性和线性回归。评估了年龄小于50岁和大于50岁的女性之间BMS的差异。通过变异系数（CV）和类内相关系数（ICC）评价操作员间和操作员内的再现性。结果女性中，年龄与左和右全BMS（每十年BMS下降5.61%和4.90%）和左和右皮质BMS（每十年BMS下降10.50%和10.09%）呈负相关。50岁以上女性的BMS低于50岁以下女性的BMS（P< .0001）。在男性中，年龄与左侧和右侧整体BMS（每十年BMS下降4.29%和4.25%）以及左侧和右侧皮质BMS（每十年BMS下降9.13%和10.30%）呈负相关。骨密度与整体（r= 0.80，P <0.0001）和皮质（r= 0.92，P <0.0001）BMS呈正相关。当BMD测试提供骨疾病的临界确定时，本文所述的方法可能潜在地用于评估个体中髋部骨折的风险。
BackgroundStandard of care metabolic bone disease assessment relies on changes to bone quantity, which can only be detected after structural changes occur.PurposeTo investigate the usefulness of Bone Metabolism Score (BMS), derived from fluorine 18 labeled sodium fluoride (18F-NaF) PET/CT imaging as a biomarker of localized metabolic changes at the femoral neck.MethodsIn this retrospective study, 139 participants (68 females and 71 males, ages 21–75 years) that had undergone18F-NaF PET/CT were included. BMS was calculated as the ratio of standard uptake value (SUV) in the bone region to that of the total region. Correlations and linear regressions of BMS with age, CT-derived bone mineral density (BMD), body mass index (BMI), height, and weight were conducted. Differences in BMS between women younger and older than the age of 50 years were assessed. Inter- and intra-operator reproducibility was evaluated by coefficient of variation (CV) and intra-class correlation coefficient (ICC).ResultsAmong females, age was negatively correlated with left and right whole BMS (5.61% and 4.90% drop in BMS per decade of life) and left and right cortical BMS (10.50% and 10.09% drop in BMS per decade of life). BMS of women older than 50 years was lower than BMS of women younger than 50 years (P< .0001). Among males, age was negatively correlated with left and right whole BMS (4.29% and 4.25% drop in BMS per decade of life) and left and right cortical BMS (9.13% and 10.30% drop in BMS per decade of life). BMD was positively correlated with whole (r= 0.80,P< .0001) and cortical (r= 0.92,P< .0001) BMS.ConclusionsBMS could provide functional insight regarding bone metabolism in the femoral neck to complement bone health status assessed through conventional structural imaging. The methodology described herein could be potentially useful for assessing hip fracture risk in individuals when BMD tests provide borderline determination of bone disease.