Progress of the National Pediatric Free Antiretroviral Therapy program in China
Progress of the National Pediatric Free Antiretroviral Therapy program in China
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DOI：
10.1080/09540121003615129
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发表时间：
2010-01-01
影响因子：
1.7
通讯作者：
Zhang, Fujie
中科院分区：
文献类型：
--
作者：
Zhao, Yan;Sun, Xin;Zhang, Fujie
2003年，中国政府启动了针对成年艾滋病患者的免费抗逆转录病毒治疗项目。儿童抗逆转录病毒制剂尚未提供。直到2005年7月，随着中国卫生部实施的两阶段计划的启动，儿科制剂才在中国获得。最初，在儿童艾滋病毒/艾滋病发病率最高的六个省试点了儿童抗逆转录病毒疗法方案。试点阶段允许中国疾病预防控制中心（CCDC）最终确定入选标准，治疗方案以及患者监测和随访程序。第二阶段于2006年底开始，当时该方案在全国范围内得到推广。为了保证儿科患者得到治疗，向医生提供了选择适当抗逆转录病毒药物方案和剂量的广泛培训，通常是通过与国内和国际专家的现场合作。CCDC同时建立了儿科ARV管理系统和儿科ART信息系统。对这些儿科患者进行常规的CD4计数和其他实验室检查。截至2009年6月底，已有1，529名儿童患者在国家方案下接受了抗逆转录病毒治疗。然而，挑战依然存在。首先，许多感染艾滋病毒/艾滋病的儿童生活在农村地区，那里的医疗设施和熟练医务人员数量有限，影响了治疗质量。其次，大部分儿科抗逆转录病毒药物的供应依赖于捐赠。中国政府需要努力建立自己的药品采购和供应体系。
In 2003, the Chinese Government initiated a free antiretroviral therapy (ART) program focusing on adult AIDS patients. Pediatric antiretroviral (ARV) formulations were yet unavailable. It was not until July 2005, with the initiation of a two-stage program implemented by the Chinese Ministry of Health, that pediatric formulations became accessible in China. Initially, the pediatric ART program was piloted in six provinces with the highest incidences of pediatric HIV/AIDS. The pilot stage allowed the Chinese Center for Disease Control and Prevention (CCDC) to finalize entry criteria, treatment regimen, and patient monitoring and follow-up procedures. The second stage commenced at the end of 2006 when the program was scaled-up nationally. In order to guarantee treatment of pediatric patients, extensive training in the selection of appropriate ARV drug regimen and dosage was provided to doctors, often through on-site collaboration with domestic and international experts. The CCDC simultaneously established a pediatric ARV management system and a pediatric ART information system. CD4 count and other laboratory tests are being routinely performed on these pediatric patients. By the end of June 2009, 1529 pediatric patients had received ARV under the national program. However, challenges remain. Firstly, many children infected with HIV/AIDS live in rural areas where the treatment quality is hindered by the limited number of medical facilities and skilled medical workers. Secondly, much of the pediatric ARV drug supply depends on donation. An effort needs to be made by the Chinese Government to establish China's own drug procurement and supply system.