Botanical flavonoids on coronary heart disease.
Botanical flavonoids on coronary heart disease.
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DOI：
10.1142/s0192415x1100910x
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Yuan CS
中科院分区：
文献类型：
--
作者：
Wang CZ;Mehendale SR;Calway T;Yuan CS
缺血性心脏病（IHD）是西方国家的主要死亡原因之一。预防而不是治疗心脏病可以显著提高患者的生活质量，降低医疗费用。香精广泛存在于蔬菜、水果和中草药中。经常食用植物药，特别是含有黄酮类化合物的植物药与心血管疾病的减少有关;因此，研究黄酮类化合物如何改善心脏对心脏病的抵抗力及其相关的作用机制是很重要的。研究表明，缺血再灌注可导致心肌细胞损伤和死亡，是缺血性心脏病的特征性表现。再灌注开始时释放大量活性氧（ROS），导致细胞损伤和死亡。“编程”心脏以产生较少的ROS或增加策略性ROS清除可以减少再灌注反应。此外，再灌注时大量的一氧化氮（NO）释放可以在“预处理”模型中起到保护作用。植物类黄酮诱导心脏预适应，从而保护心脏免受缺血再灌注损伤。在这篇文章中，我们将讨论两种含有有效黄酮类化合物的草药，黄芩和葡萄籽原花青素，它们可能对缺血性心脏病提供心脏保护。
Ischemic heart disease (IHD) is one of the leading causes of death in Western countries. Prevention rather than treatment of heart disease can significantly improve patients’ quality of life and reduce health care costs. Flavonoids are widely distributed in vegetables, fruits and herbal medicines. Regularly consuming botanicals, especially those containing flavonoids has been associated with a reduction in cardiovascualar disease; thus, it is important to investigate how flavonoids improve cardiac resistance to heart disease and their related mechanisms of action. It has been shown that cardiomyocyte injury and death can result from ischemia-reperfusion, which is pathognomonic of ischemic heart disease. Massive reactive oxygen species (ROS) release at the onset of reperfusion produces cell injury and death. “Programming” the heart to either generate less ROS or to increase strategic ROS removal could reduce reperfusion response. Additionally, profuse nitric oxide (NO) release at reperfusion could be protective in “preconditioning” models. Botanical flavonoids induce preconditioning of the heart, thereby protecting against ischemia-reperfusion injury. In this article, we will discuss two herbs containing potent flavonoids, Scutellaria baicalensis and grape seed proanthocyanidin, which can potentially offer cardiac protection against ischemic heart disease.