Nifedipine-induced inhibition of parasympathetic-mediated vasodilation in the orofacial areas of the cat.
Nifedipine-induced inhibition of parasympathetic-mediated vasodilation in the orofacial areas of the cat.
复制标题
硝苯地平诱导抑制猫口面部区域副交感神经介导的血管舒张。
DOI：
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
I. Nakamura
中科院分区：
文献类型：
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作者：
H. Izumi;I. Nakamura
在麻醉猫中，我们 1) 比较了抗高血压药物（硝苯地平、可乐定、酚妥拉明、普萘洛尔和硝普钠）对下唇和舌头舌神经 (LN) 刺激引起的副交感血管舒张的影响，2) 研究了硝苯地平抑制副交感下唇血管舒张的机制。在所使用的剂量下，每种抗高血压药物可使全身动脉血压降低约 20 mmHg；然而，只有硝苯地平才能显着减少 LN 刺激引起的副交感血管舒张。当以 1 Hz 频率持续重复刺激上颈交感干期间刺激 LN 时，未观察到硝苯地平的这种抑制作用。这表明，这种钙通道阻滞剂不会直接损害唇和舌血管放松副交感神经刺激的能力，并且此处看到的硝苯地平的抑制作用可能是由于对血管平滑肌突触后位点的作用引起的，该作用导致先前存在的交感血管收缩张力降低（通过抑制钙流入血管平滑肌细胞）。
In anesthetized cats, we 1) compared the effects of antihypertensive agents (nifedipine, clonidine, phentolamine, propranolol, and nitroprusside) on the parasympathetic vasodilations elicited by lingual nerve (LN) stimulation in the lower lip and tongue and 2) investigated the mechanisms underlying the inhibitory effect of nifedipine on parasympathetic lower lip vasodilation. At the doses used, each antihypertensive agent reduced systemic arterial blood pressure by approximately 20 mmHg; however, the parasympathetic vasodilation elicited by LN stimulation was significantly reduced only by nifedipine. This inhibitory effect of nifedipine was not seen when LN was stimulated during ongoing repetitive stimulation of the superior cervical sympathetic trunk at 1-Hz frequency. This suggests that the ability of lip and tongue blood vessels to relax to parasympathetic stimulation is not directly impaired by this calcium channel blocker and that the inhibitory effects of nifedipine seen here probably resulted from an action on postsynaptic sites in vascular smooth muscle that caused a reduction in preexisting sympathetic vasoconstrictor tone (by inhibiting calcium influx into the vascular smooth muscle cell).
三叉神经节中选择性 5-HT1D α 血清素受体基因表达：对抗偏头痛药物开发的影响。
DOI：
10.1073/pnas.91.9.3666
发表时间：
1994
影响因子：
11.1
作者：
Rebeck,GW;Maynard,KI;Hyman,BT;Moskowitz,MA
通讯作者：
Moskowitz,MA