Longitudinal changes in body composition and metabolic profile between exercise clinical trials in men with chronic spinal cord injury
Longitudinal changes in body composition and metabolic profile between exercise clinical trials in men with chronic spinal cord injury
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DOI：
10.1080/10790268.2016.1157970
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发表时间：
2016-01-01
影响因子：
1.7
通讯作者：
Gater, David R.
中科院分区：
文献类型：
--
作者：
Gorgey, Ashraf S.;Martin, Heather;Gater, David R.
研究设计：纵向设计。目的：本研究旨在确定停止运动干预对慢性 SCI 男性身体成分和代谢特征的影响。地点：医疗中心内的临床试验。方法：对 11 名运动性完全性 SCI 男性进行平均随访 2.5 年。六名男性参与了两种不同的运动干预（功能性电刺激自行车与手臂自行车测力计），每周 5 天，持续 16 周（运动组），五名男性作为对照（对照组）。通过人体测量学和双能 X 射线吸收测量法 (DXA) 来测量运动前、运动后立即和 2.5 年后的瘦体重 (LM)、脂肪量 (FM) 和 FM 百分比的变化。还测量了基础代谢率 (BMR) 和血脂水平。结果：运动后大腿围增加了 8.5% (P = 0.042)，并且仍比基线测量值大 6.4% (P = 0.012)。运动干预后腿部 LM 增加了 9% (P = 0.03)，在随访中下降了 16% (P = 0.02)。在随访中，躯干和全身 FM 百分比分别增加了 4.5%（P = 0.008）和 3.5%（P = 0.019），全身 LM 增加了 8.4%，2.5 年后又下降了 5.4%。运动干预后BMR显着下降15.5%（P=0.029）。结论：运动训练伴随着身体成分的积极变化以及BMR的代偿性下降，在停止运动2.5年后又恢复了。参加运动试验不太可能混淆后续试验的测量结果。
Study design: Longitudinal design.Objectives: The study was undertaken to determine the effects of cessation of exercise interventions on body composition and metabolic profiles in men with chronic SCI.Settings: Clinical trials within a Medical Center.Methods: Eleven men with motor complete SCI were followed on average over a period of 2.5 years. Six men were involved in two different exercise interventions (functional electrical stimulation cycling versus arm cycling ergometer), 5 days/week for 16 weeks (exercise group), and five men served as a control (control group). Anthropometrics and dual energy X-ray absorptiometry (DXA) were captured to measure changes in lean mass (LM), fat mass (FM), percentage FM before, immediately after exercise, and after a period of 2.5 years. Basal metabolic rate (BMR) and lipid panel were also measured.Results: Thigh circumference increased by 8.5% following exercise (P = 0.042) and remained 6.4% greater than baseline measurements (P = 0.012). Leg LM increased by 9% following the exercise intervention (P = 0.03) and decreased by 16% in the follow-up visit (P = 0.02). Percentage trunk and total body FM increased by 4.5% (P = 0.008) and 3.5% (P = 0.019) in the follow-up visit, respectively, and whole body LM increased by 8.4% and decreased back by 5.4% following a 2.5 year-period. BMR significantly decreased by 15.5% following the exercise (P = 0.029) interventions.Conclusion: Exercise training is accompanied with positive changes in body composition as well as compensatory decrease in BMR, that regressed back following 2.5 years of exercise cessation. Participation in an exercise trial is unlikely to confound the measurements of a follow-up trial.