Lymphocyte homing and homeostasis
Lymphocyte homing and homeostasis
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DOI：
10.1126/science.272.5258.60
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发表时间：
1996-04-05
期刊：
影响因子：
56.9
通讯作者：
Picker, LJ
中科院分区：
文献类型：
--
作者：
Butcher, EC;Picker, LJ
全身性免疫应答的整合与控制依赖于淋巴细胞的受调控运输。这种淋巴细胞的“归巢”过程分散了免疫细胞库，引导淋巴细胞亚群进入控制其分化并调节其存活的特定微环境，并将免疫效应细胞导向抗原或微生物入侵部位。近期研究进展表明，淋巴细胞归巢的高度特异性是由涉及黏附受体和信号受体多步顺序结合的组合“决策过程”所决定的。这些与归巢相关的相互作用无缝整合到淋巴细胞与其环境的整体相互作用中，并直接参与淋巴细胞功能、寿命和群体动态的控制。本文综述了淋巴细胞归巢的分子基础，并提出了归巢生理学调节免疫资源内稳态的机制。
The integration and control of systemic immune responses depends on the regulated trafficking of lymphocytes. This lymphocyte ''homing'' process disperses the immunologic repertoire, directs lymphocyte subsets to the specialized microenvironments that control their differentiation and regulate their survival, and targets immune effector cells to sites of antigenic or microbial invasion. Recent advances reveal that the exquisite specificity of lymphocyte homing is determined by combinatorial ''decision processes'' involving multistep sequential engagement of adhesion and signaling receptors. These homing-related interactions are seamlessly integrated into the overall interaction of the lymphocyte with its environment and participate directly in the control of lymphocyte function, life-span, and population dynamics. In this article a review of the molecular basis of lymphocyte homing is presented, and mechanisms by which homing physiology regulates the homeostasis of immunologic resources are proposed.