miR-485-5p suppresses breast cancer progression and chemosensitivity by targeting survivin
miR-485-5p suppresses breast cancer progression and chemosensitivity by targeting survivin
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miR-485-5p 通过靶向生存素抑制乳腺癌进展和化疗敏感性。
DOI：
10.1016/j.bbrc.2018.04.129
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发表时间：
2018-06-18
影响因子：
3.1
通讯作者：
Cao, Xu-Chen
中科院分区：
文献类型：
--
作者：
Wang, Meng;Cai, Wen-Run;Cao, Xu-Chen
乳腺癌是全世界女性中最常见的癌症。化疗耐药仍然是乳腺癌治疗中的一个相当大的障碍，它经常涉及到各种microRNAs(MiRNAs)的失调。MIR-485-5P在几种类型的人类癌症中发挥肿瘤抑制作用。然而，它在乳腺癌化疗敏感性中的作用尚未确定。在目前的研究中，我们在体外和体内都证明了miR-485-5p的过表达抑制了乳腺癌的进展并增强了对化疗的敏感性。进一步的研究表明，miR-485-5p直接靶向Survivin的3‘非翻译区，并且Survivin的表达克服了miR-485-5P对乳腺癌的诱导作用。综上所述，我们的研究证实miR-485-5p通过靶向Survivin来抑制肿瘤进展并增强化疗敏感性。MiR-485-5p靶向Survivin可能为逆转乳腺癌细胞的化疗敏感性提供了一种潜在的途径。(C)2018 Elsevier Inc.保留所有权利。
Breast cancer is the most common cancer among women worldwide. Chemoresistance remains to be a considerable obstacle in breast cancer therapy and it is often involves dysregulation of a variety of microRNAs (miRNAs). miR-485-5p functions as a tumor suppressor in several types of human cancers. However, its role in breast cancer chemosensitivity have not been determined. In the present study, we demonstrated that overexpression of miR-485-5p suppresses breast cancer progression and enhances chemosensitivity both in vitro and in vivo. Further study demonstrated that miR-485-5p directly targeted the 3'-untranslated region of survivin and overexpression of survivin overcomes the miR-485-5p induced effects on breast cancer. In conclusion, our study identified that miR-485-5p suppresses cancer progression and enhances the chemosensitivity by targeting survivin. Targeting survivin by miR-485-5p may provide a potential approach to reverse chemosensitivity in breast cancer cells. (C) 2018 Elsevier Inc. All rights reserved.