Aquaporin-9 is expressed in a mucus-secreting goblet cell subset in the small intestine
Aquaporin-9 is expressed in a mucus-secreting goblet cell subset in the small intestine
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DOI：
10.1016/s0014-5793(03)00256-4
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发表时间：
2003-04-10
期刊：
影响因子：
3.5
通讯作者：
Abe, K
中科院分区：
文献类型：
--
作者：
Okada, S;Misaka, T;Abe, K
我们分析了水通道蛋白（AQP）在小肠中的表达，以阐明其功能，并发现AQP 9，这是以前没有检测到，存在于十二指肠，空肠和回肠。AQP 9也在结肠中表达，但在胃中不表达。此外，其在这些肠切片中的表达仅限于杯状细胞亚群的基底外侧膜。我们发现AQP 9作为粘液分泌细胞特异性地存在于杯状细胞中，这表明其参与某种粘液的合成和/或分泌，该粘液可以保护肠表面并使肠内容物的流动顺畅。(C)2003年欧洲生物化学学会联合会。由Elsevier Science B. V.出版，版权所有。
We analyzed the expression of aquaporins (AQPs) in the small intestine to elucidate their functions, and found that AQP9, which had not previously been detected there, is present in duodenum, jejunum, and ileum. AQP9 is expressed in colon as well, but not in stomach. Also, its expression in these intestinal sections is limited to the basolateral membranes of a goblet cell subset. Our finding that AQP9 is present specifically in goblet cells as mucus-secreting cells suggests its involvement in the synthesis and/or secretion of a certain kind of mucus which may protect the intestinal surface and smooth the flow of intestinal contents. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.