The neural crest: basic biology and clinical relationships in the craniofacial and enteric nervous systems.
The neural crest: basic biology and clinical relationships in the craniofacial and enteric nervous systems.
复制标题
DOI：
10.1002/bdrc.20013
复制
发表时间：
2004-06-01
期刊：
影响因子：
--
通讯作者：
Newgreen, Donald F
中科院分区：
文献类型：
--
作者：
Farlie, Peter G;McKeown, Sonja J;Newgreen, Donald F
高度迁移的间充质神经嵴细胞群在100多年前被发现。关于这些细胞起源于神经上皮以及它们产生的组织的提议引发了长达数十年的激烈争论，因为这些提议挑战了强大的生殖层理论。在经历了这场风暴之后，神经嵴现在被认为是一个多能干细胞群，对神经和非神经器官系统的惊人阵列做出了重要贡献。研究神经嵴的最早模型系统是两栖动物，这些开创性的贡献已经通过鸡，小鼠和最近的鱼类研究得到了巧妙的改进和扩展，以提供对神经嵴调节和调节的细胞和分子机制的详细理解。关于控制颅面形态发生和肠道神经支配的关键问题说明了神经嵴在广泛的发育背景中起着重要作用。这些问题也集中关注一些常见问题，如生长因子信号在神经嵴细胞发育中的作用，并突出了神经嵴在人类先天性疾病中的核心作用。
The highly migratory, mesenchymal neural crest cell population was discovered over 100 years ago. Proposals of these cells' origin within the neuroepithelium, and of the tissues they gave rise to, initiated decades-long heated debates, since these proposals challenged the powerful germ-layer theory. Having survived this storm, the neural crest is now regarded as a pluripotent stem cell population that makes vital contributions to an astounding array of both neural and non-neural organ systems. The earliest model systems for studying the neural crest were amphibian, and these pioneering contributions have been ably refined and extended by studies in the chick, mouse, and more recently the fish to provide detailed understanding of the cellular and molecular mechanisms regulating and regulated by the neural crest. The key questions regarding control of craniofacial morphogenesis and innervation of the gut illustrate the wide range of developmental contexts in which the neural crest plays an important role. These questions also focus attention on common issues such as the role of growth factor signaling in neural crest cell development and highlight the central role of the neural crest in human congenital disease.